{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T06:23:48Z","timestamp":1781677428176,"version":"3.54.5"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":1920,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T00:00:00Z","timestamp":1604016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In human patients, cumulative urine volume (uVol) and urine sodium (uNa) can be predicted using spot urine samples and these quantitative measures help detect low diuretic responsiveness (LDR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/objectives<\/jats:title>\n                    <jats:p>Formulas using spot urine samples predict cumulative uVol and uNa output after oral administration of furosemide to dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Eight healthy dogs, 6 dogs with congestive heart failure (CHF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective interventional study. Spot urine samples at 180 and 270 minutes after furosemide (3 mg\/kg PO) were used to predict cumulative uVol and uNa output over 7 hours. Differentiation of dogs fulfilling predefined criteria for LDR was examined using receiver operating characteristic (ROC) curves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Predicted uNa output at 180 minutes (rs =\u20090.763, [95% confidence interval [CI], 0.375-0.923], P =\u2009.002) and 270 minutes (r =\u20090.816, [95% CI, 0.503-0.940], P &amp;lt;\u2009.001) was highly correlated to 7-hour uNa output. Predicted uVol at 180 minutes (r =\u20090.598, [95% CI, 0.098-0.857], P =\u2009.02) and 270 minutes (r =\u20090.791, [95% CI, 0.450-0.931], P &amp;lt;\u2009.001) was moderately correlated to 7-hour uVol. Predicted uNa using 180-minute (area under the curve [AUC], 0.933 [95% CI, 0.804-1.000]) and 270-minute (AUC, 0.911 [95% CI, 0.756-1.000]) samples identified dogs with LDR (n = 5) with high accuracy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Urinary Na excretion and uVol are complementary but distinct aspects of diuretic responsiveness in dogs. Quantification of diuretic responsiveness in the clinical setting opens new diagnostic, treatment, and monitoring strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.15952","type":"journal-article","created":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T15:30:28Z","timestamp":1604071828000},"page":"2253-2264","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prediction and measurement of diuretic responsiveness after oral administration of furosemide to healthy dogs and dogs with congestive heart failure"],"prefix":"10.1093","volume":"34","author":[{"given":"Kerry A.","family":"Loughran","sequence":"first","affiliation":[{"name":"School of Veterinary Medicine, University of Pennsylvania Department of Clinical Sciences and Advanced Medicine, , Philadelphia, Pennsylvania,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9va","family":"Larouche-Lebel","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University of Pennsylvania Department of Clinical Sciences and Advanced Medicine, , Philadelphia, Pennsylvania,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry","family":"Huh","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University of Pennsylvania Department of Clinical Sciences and Advanced Medicine, , Philadelphia, Pennsylvania,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Testani","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Medicine , Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veena S.","family":"Rao","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Medicine , Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5218-9226","authenticated-orcid":false,"given":"Mark A.","family":"Oyama","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University of Pennsylvania Department of Clinical Sciences and Advanced Medicine, , Philadelphia, Pennsylvania,","place":["USA"]},{"name":"Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania , Philadelphia, Pennsylvania,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,11,1]]},"reference":[{"key":"2026020922120721500_jvim15952-bib-0001","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s10741-014-9438-7","article-title":"Water and sodium in heart failure: a spotlight on congestion","volume":"20","author":"Parrinello","year":"2015","journal-title":"Heart Fail Rev"},{"key":"2026020922120721500_jvim15952-bib-0002","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1161\/01.CIR.80.2.299","article-title":"Edema of cardiac origin. 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