{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:46:03Z","timestamp":1770745563330,"version":"3.49.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":1859,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2020,12,19]],"date-time":"2020-12-19T00:00:00Z","timestamp":1608336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Equestra Pty Ltd"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Omeprazole preparations vary in bioavailability in horses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>To characterize the pharmacokinetics and pharmacodynamics of an existing enteric-coated oral omeprazole paste (REF) and a novel, in-feed, enteric-coated dry granule preparation (NOV).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Twelve Standardbred\/Thoroughbred mares free from clinical disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective, blinded randomized interventional study was trial, conducted in 3 parts: (a) bioavailability study, (b) dose titration study, and (c) comparative clinical pharmacodynamic study, each using a blocked crossover design.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Consistent with the larger dose administered, Cmax (median, 1032\u2009ng\/mL; range, 576-1766) and AUC0-24 (median, 63.9 \u03bcg\/mL*min; range, 42.4-152.4) were greater after single oral administration of NOV than REF (282.7 ng\/mL; range, 94.8-390.2, and 319 23.8 \u03bcg\/mL*min; range, 8.2-42.3, respectively; both P = .004). No differences were observed between products for absolute oral bioavailability (NOV 55% range, 15-88; REF 17% range, 10-77; P = .25). Treatment with both preparations was associated with reduced gastric squamous ulcer scores and increased pH of gastric fluid. Bioequivalence was demonstrated for pharmacodynamic measures with the exception of % time pH &amp;lt;4, despite differences in dose rate and subsequent plasma omeprazole concentrations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>The findings of this study indicate that the NOV product would be a suitable alternative to the reference product, and confirm that plasma concentrations of omeprazole and omeprazole dose do not predict drug pharmacodynamics in horses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.15971","type":"journal-article","created":{"date-parts":[[2020,12,19]],"date-time":"2020-12-19T07:46:13Z","timestamp":1608363973000},"page":"620-631","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Pharmacokinetic and pharmacodynamic effects of 2 registered omeprazole preparations and varying dose rates in horses"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3483-9384","authenticated-orcid":false,"given":"Jessica C.","family":"Wise","sequence":"first","affiliation":[{"name":"School of Animal and Veterinary Sciences, Charles Sturt University , Wagga Wagga, New South Wales,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristopher J.","family":"Hughes","sequence":"additional","affiliation":[{"name":"School of Animal and Veterinary Sciences, Charles Sturt University , Wagga Wagga, New South Wales,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Edwards","sequence":"additional","affiliation":[{"name":"School of Animal and Veterinary Sciences, Charles Sturt University , Wagga Wagga, New South Wales,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenn A.","family":"Jacobson","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmacology, University of Tasmania , Hobart, Tasmania,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian K.","family":"Narkowicz","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmacology, University of Tasmania , Hobart, Tasmania,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5558-3133","authenticated-orcid":false,"given":"Sharanne L.","family":"Raidal","sequence":"additional","affiliation":[{"name":"School of Animal and Veterinary Sciences, Charles Sturt University , Wagga Wagga, New South 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