{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:20:06Z","timestamp":1792012806823,"version":"4.4.0"},"reference-count":83,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":1859,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T00:00:00Z","timestamp":1606348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007825","name":"American College of Veterinary Internal Medicine","doi-asserted-by":"publisher","award":["GRT00049516"],"award-info":[{"award-number":["GRT00049516"]}],"id":[{"id":"10.13039\/100007825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008788","name":"College of Veterinary Medicine, Ohio State University","doi-asserted-by":"publisher","award":["2017-19"],"award-info":[{"award-number":["2017-19"]}],"id":[{"id":"10.13039\/100008788","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007825","name":"American College of Veterinary Internal Medicine","doi-asserted-by":"publisher","award":["GRT00049516"],"award-info":[{"award-number":["GRT00049516"]}],"id":[{"id":"10.13039\/100007825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008788","name":"College of Veterinary Medicine, Ohio State University","doi-asserted-by":"publisher","award":["2017\u201019"],"award-info":[{"award-number":["2017\u201019"]}],"id":[{"id":"10.13039\/100008788","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Arterial thromboembolism is a sequela of hypertrophic cardiomyopathy (HCM) in cats related to left atrial (LA) enlargement and dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis<\/jats:title>\n                    <jats:p>Pimobendan improves LA transport function in cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Twenty-two client-owned cats with HCM and 11 healthy cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective, double-blind, randomized, placebo-controlled clinical cohort study. Cats were randomized to receive either pimobendan (0.25\u2009mg\/kg PO q12h) or placebo for 4 to 7\u2009days. Nineteen echocardiographic variables of LA size and function were evaluated. Statistical comparisons included t tests, analysis of variance, and multivariable analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Peak velocity of left auricular appendage flow (LAapp peak; mean\u2009\u00b1\u2009SD, 0.85\u2009\u00b1\u20090.20 vs 0.71\u2009\u00b1\u20090.22\u2009m\/s; P = .01), maximum LA volume (P = .03), LA total emptying volume (P = .03), peak velocity of late diastolic transmitral flow (A peak velocity; 0.77\u2009\u00b1\u20090.12 vs 0.62\u2009\u00b1\u20090.17\u2009m\/s; P = .05), and A velocity time integral (A VTI; 3.05\u2009\u00b1\u20090.69 vs 3.37\u2009\u00b1\u20090.49; P = .05) were increased after pimobendan. Mean change after pimobendan was larger in cats with HCM compared to healthy cats for LA fractional shortening (2.1% vs \u22122.1%; P = .05), A VTI (0.58 vs 0.01\u2009cm; P = .01), LAapp peak (0.20 vs 0.02\u2009m\/s; P = .02), LA kinetic energy (3.51 vs \u22120.10 kdynes-cm; P = .05), and LA ejection force (1.93 vs \u22120.07\u2009kdynes; P = .01) in the multivariable model. The stronger effect of pimobendan in cats with HCM was independent of LA size.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>We identified positive, albeit minor, effects of pimobendan on LA function in cats with HCM. Whether or not treatment with pimobendan decreases the risk of cardiogenic embolism deserves further study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.15976","type":"journal-article","created":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T07:40:24Z","timestamp":1606376424000},"page":"10-21","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effects of pimobendan on left atrial transport function in cats"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1299-2452","authenticated-orcid":false,"given":"Samantha L.","family":"Kochie","sequence":"first","affiliation":[{"name":"The Ohio State University Department of Veterinary Clinical Sciences, , Columbus, Ohio,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1286-0759","authenticated-orcid":false,"given":"Karsten E.","family":"Schober","sequence":"additional","affiliation":[{"name":"The Ohio State University Department of Veterinary Clinical Sciences, , Columbus, Ohio,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5549-3493","authenticated-orcid":false,"given":"Jaylyn","family":"Rhinehart","sequence":"additional","affiliation":[{"name":"The Ohio State University Department of Veterinary Clinical Sciences, , Columbus, Ohio,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randolph L.","family":"Winter","sequence":"additional","affiliation":[{"name":"The Ohio State University Department of Veterinary Clinical Sciences, , Columbus, Ohio,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Bonagura","sequence":"additional","affiliation":[{"name":"The Ohio State University Department of Veterinary Clinical Sciences, , Columbus, Ohio,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Showers","sequence":"additional","affiliation":[{"name":"The Ohio State University Department of Veterinary Clinical Sciences, , Columbus, Ohio,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vedat","family":"Yildez","sequence":"additional","affiliation":[{"name":"Center for Biostatistics, The Ohio State University , Columbus, Ohio,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,1,1]]},"reference":[{"key":"2026020922095003400_jvim15976-bib-0001","doi-asserted-by":"crossref","first-page":"S202","DOI":"10.1016\/j.jvc.2015.10.006","article-title":"Cardiogenic embolism in the cat","volume":"17","author":"Hogan","year":"2015","journal-title":"J Vet Cardiol"},{"issue":"1","key":"2026020922095003400_jvim15976-bib-0002","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1177\/1098612X12451547","article-title":"Arterial thromboembolism: risks, realities and a rational first-line approach","volume":"14","author":"Fuentes","year":"2012","journal-title":"J Feline Med Surg"},{"key":"2026020922095003400_jvim15976-bib-0003","doi-asserted-by":"crossref","first-page":"492","DOI":"10.5326\/15473317-31-6-492","article-title":"A retrospective study of 100 cases of feline distal aortic thromboembolism: 1977\u20131993","volume":"31","author":"Laste","year":"1995","journal-title":"J Am Anim Hosp Assoc"},{"key":"2026020922095003400_jvim15976-bib-0004","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/jvim.12249","article-title":"Arterial thromboembolism in 250 cats in general practice: 2004\u20132012","volume":"28","author":"Borgeat","year":"2014","journal-title":"J Vet Intern Med"},{"key":"2026020922095003400_jvim15976-bib-0005","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/j.1748-5827.2010.00989.x","article-title":"Population characteristics and survival in 127 referred cats with hypertrophic cardiomyopathy (1997 to 2005)","volume":"51","author":"Payne","year":"2010","journal-title":"J Small Anim Pract"},{"key":"2026020922095003400_jvim15976-bib-0006","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1161\/01.CIR.92.9.2645","article-title":"Echocardiographic assessment of spontaneously occurring feline hypertrophic cardiomyopathy. 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