{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:37:23Z","timestamp":1770745043452,"version":"3.49.0"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":1859,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T00:00:00Z","timestamp":1607040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003551","name":"Royal Canin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003551","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003551","name":"Royal Canin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003551","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Systemic hypertension (SH) is common in dogs and humans with hypercortisolism and can persist after treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate changes in prevalence of SH and systolic blood pressure (SBP) in dogs with pituitary-dependent hyperadrenocorticism (PDH) during the first year of trilostane treatment, its relationship with disease control and selected laboratory variables, and their response to antihypertensive treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Fifty-one dogs with PDH treated with trilostane Q12h.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective case series study. Dogs were evaluated at diagnosis (T0) and 1, 3, 6, and 12\u2009months (T12). Dogs were classified as nonhypertensive (SBP\u2009&amp;lt;\u2009160\u2009mm Hg) or hypertensive (SBP\u2265160\u2009mm Hg) and subclassified according to target organ damage (TOD) risk. Hypertensive dogs were treated with benazepril and, if control of SH was not achieved, amlodipine was added.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Prevalence of SH decreased from T0 (36\/51) to T12 (17\/37; P = .01). Changes in SBP during the study were influenced by the risk of TOD at T0. In severely hypertensive (SBP\u2009\u2265\u2009180\u2009mm Hg) dogs, the decrease in SBP was more pronounced whereas in normotensive (SBP\u2009&amp;lt;\u2009140\u2009mm Hg) dogs SBP increased slightly (P = .00). Blood pressure was not associated with disease control. Antihypertensive treatment was needed in 31\/51 dogs, and in 13\/31 dogs additional SH control with amlodipine was required. One third of nonhypertensive dogs at T0 required treatment with benazepril because SH developed during follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>In dogs with PDH, SBP should be measured at every visit, regardless of disease control or SBP at diagnosis. More than 1 drug may be necessary to manage SH in affected dogs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.15978","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T07:10:50Z","timestamp":1607065850000},"page":"130-141","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Changes in systolic blood pressure in dogs with pituitary dependent hyperadrenocorticism during the first year of trilostane treatment"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8531-9069","authenticated-orcid":false,"given":"Paula","family":"Garc\u00eda San Jos\u00e9","sequence":"first","affiliation":[{"name":"Veterinary Faculty, Complutense University of Madrid Department of Animal Medicine and Surgery, , Madrid,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5071-7689","authenticated-orcid":false,"given":"Carolina","family":"Arenas Bermejo","sequence":"additional","affiliation":[{"name":"Anicura Hospital Veterinario Valencia Sur , Valencia,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4106-2278","authenticated-orcid":false,"given":"Daniel","family":"Alonso-Miguel","sequence":"additional","affiliation":[{"name":"Veterinary Faculty, Complutense University of Madrid Department of Animal Medicine and Surgery, , Madrid,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Clares Moral","sequence":"additional","affiliation":[{"name":"Veterinary Teaching Hospital Complutense, Complutense University of Madrid , 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