{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T18:26:19Z","timestamp":1785608779479,"version":"3.56.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":1859,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T00:00:00Z","timestamp":1607040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Cisco and Izzy Fund for Immunologic Research"},{"name":"NIH ORIP K01 Mentored Research Scientist Development Award","award":["1K01OD019912"],"award-info":[{"award-number":["1K01OD019912"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>An approximately 1-year-old male intact Shih Tzu dog was referred to a tertiary facility with a history of progressive tachypnea, increased respiratory effort, and weight loss over a 3-month period that failed to improve with empirical antimicrobial treatment. Upon completion of a comprehensive respiratory evaluation, the dog was diagnosed with severe Pneumocystis pneumonia and secondary pulmonary hypertension. Clinical signs resolved and disease resolution was confirmed after completion of an 8-week course of trimethoprim-sulfonamide, 4-week tapering dose of prednisone to decrease an inflammatory response secondary to acute die-off of organisms, a 2-week course of clopidogrel to prevent clot formation, and a 2-week course of a phosphodiesterase-5 inhibitor to treat pulmonary hypertension. Immunodiagnostic testing and genetic sequencing were performed to evaluate for potential immunodeficiency as an underlying cause for the development Pneumocystis pneumonia, and identified an X-linked CD40 ligand deficiency.<\/jats:p>","DOI":"10.1111\/jvim.15988","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T04:59:51Z","timestamp":1607057991000},"page":"497-503","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["X-linked CD40 ligand deficiency in a 1-year-old male Shih Tzu with secondary\n                    <i>Pneumocystis<\/i>\n                    pneumonia"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9129-7409","authenticated-orcid":false,"given":"Kristen","family":"Merrill","sequence":"first","affiliation":[{"name":"University of Missouri, Ringgold Standard Institution - Small Animal Internal Medicine Department of Veterinary 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Quebec,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hansj\u00f6rg","family":"Rindt","sequence":"additional","affiliation":[{"name":"University of Missouri, College of Veterinary Medicine, Veterinary Medicine and Surgery , Columbia, Missouri,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6382-5582","authenticated-orcid":false,"given":"Carol","family":"Reinero","sequence":"additional","affiliation":[{"name":"University of Missouri, Veterinary Medicine and Surgery , Columbia, Missouri,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,1,1]]},"reference":[{"key":"2026020922103802300_jvim15988-bib-0001","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/j.1748-5827.1996.tb02380.x","article-title":"Pneumocystis carinii in the miniature dachshund: case report and literature 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