{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T11:40:24Z","timestamp":1785498024908,"version":"3.56.0"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":1800,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T00:00:00Z","timestamp":1613692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K01-OD019912"],"award-info":[{"award-number":["K01-OD019912"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K01\u2010OD019912"],"award-info":[{"award-number":["K01\u2010OD019912"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The Blastomyces antigen concentration in urine (BACU) test is used to diagnose blastomycosis and monitor treatment in dogs. It is unknown if a higher BACU is associated with shorter survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine if the magnitude of BACU before treatment is associated with survival in dogs with blastomycosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Fifty-two dogs with blastomycosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective case review. BACU, radiographic lung severity (RLS) score (0-4 scale), and survival time up to 1\u2009year after diagnosis were obtained through medical record review of dogs with Blastomyces dermatitidis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The overall survival was: discharge, 87%; 1\u2009week, 85%; 2\u2009months, 74%; and 6 months, 69%. BACU correlated with RLS score (rs = 0.33, P = .02). BACU and RLS scores were lower in survivors to 2\u2009months than nonsurvivors (average BACU difference of 2.5\u2009ng\/mL, 95% confidence interval [CI]: 0.2-4.8\u2009ng\/mL, P = .04; median RLS difference of 2; range, 0-4, P = .02). Dogs with BACU &amp;lt;5\u2009ng\/mL and dogs with mild (0-1) RLS scores had a greater proportion surviving than those with BACU &amp;gt;5\u2009ng\/mL (P = .03) and dogs with severe (3-4) RLS scores (P = .04). All dogs with a BACU &amp;lt;5\u2009ng\/mL or mild RLS score were alive at last follow-up (median, 365\u2009days; range, 44-365\u2009days). In all, 68.1% of other dogs survived to 2\u2009months (95% CI, 54.8%-84.8%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Dogs with lower BACU and RLS scores have improved survival; however, it is unclear what specific cutoffs should be used for prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16041","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T17:49:20Z","timestamp":1613843360000},"page":"946-953","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Retrospective analysis of the effects of\n                    <i>Blastomyces<\/i>\n                    antigen concentration in urine and radiographic findings on survival in dogs with blastomycosis"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9622-6490","authenticated-orcid":false,"given":"Laura O.","family":"Motschenbacher","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, University of Minnesota Veterinary Clinical Sciences Department, , St. Paul, Minnesota,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Furrow","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, University of Minnesota Veterinary Clinical Sciences Department, , St. Paul, Minnesota,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron K.","family":"Rendahl","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, University of Minnesota Veterinary Clinical Sciences Department, , St. Paul, Minnesota,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther G.","family":"Nell","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, University of Minnesota Veterinary Clinical Sciences Department, , St. Paul, Minnesota,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari L.","family":"Anderson","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, University of Minnesota Veterinary Clinical Sciences Department, , St. Paul, Minnesota,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay K.","family":"Merkel","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, University of Minnesota Veterinary Clinical Sciences Department, , St. Paul, Minnesota,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward E.","family":"Patterson","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, University of Minnesota Veterinary Clinical Sciences 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