{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:07:15Z","timestamp":1791594435350,"version":"4.3.4"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":1800,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T00:00:00Z","timestamp":1614038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Successful treatment of cats with hypersomatotropism by transsphenoidal hypophysectomy is described in small numbers of cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To describe the endocrine profile, survival, and remission rates of hypersomatotropism and diabetes mellitus in a cohort of cats with hypersomatotropism that underwent hypophysectomy between 2008 and 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Twenty-five client-owned cats with spontaneous hypersomatotropism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective study. Diagnosis of hypersomatotropism was based on clinical signs, plasma insulin-like growth factor-1 (IGF-1) concentration, and imaging of the pituitary gland. Growth hormone (GH) and IGF-1 concentrations were measured repeatedly after surgery. Survival times were calculated based on follow-up information from owners and referring veterinarians.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Median postoperative hospital stay was 7\u2009days (range, 3-18\u2009days). One cat died within 4\u2009weeks of surgery. Median plasma GH concentration decreased significantly from 51.0 ng\/mL (range, 5.0-101.0 ng\/mL) before surgery to 3.8 ng\/mL (range, 0.6-13.0 ng\/mL) at 5 hours after surgery. Remission of hypersomatotropism, defined as normalization of plasma IGF-1 concentration, occurred in 23\/24 cats (median, 34\u2009ng\/mL; range, 14-240\u2009ng\/mL) and 22\/24 cats entered diabetic remission. Median survival time was 1347\u2009days (95% confidence interval, 900-1794\u2009days; range, 11-3180\u2009days) and the overall 1-, 2-, and 3-year all-cause survival rates were 76%, 76%, and 52%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>This study shows the beneficial outcome of hypophysectomy in cats with hypersomatotropism, marked by low death rate and a high percentage of diabetic remission and definitive cure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16047","type":"journal-article","created":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T17:37:11Z","timestamp":1614101831000},"page":"834-842","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Evaluation of hypophysectomy for treatment of hypersomatotropism in 25 cats"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9327-6799","authenticated-orcid":false,"given":"Kirsten L.","family":"van Bokhorst","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Medicine, Utrecht University Department of Clinical Sciences, , Utrecht,","place":["The Netherlands"]},{"name":"IVC Evidensia , Vleuten,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9159-5596","authenticated-orcid":false,"given":"Sara","family":"Galac","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Utrecht University Department of Clinical Sciences, , Utrecht,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8058-0492","authenticated-orcid":false,"given":"Hans S.","family":"Kooistra","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Utrecht University Department of Clinical Sciences, , Utrecht,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Valtolina","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Utrecht University Department of Clinical Sciences, , Utrecht,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3121-2199","authenticated-orcid":false,"given":"Federico","family":"Fracassi","sequence":"additional","affiliation":[{"name":"University of Bologna Department of Veterinary Medical Sciences, , Bologna,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"MICEN VET , 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