{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:57:00Z","timestamp":1792112220928,"version":"4.4.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":1800,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T00:00:00Z","timestamp":1612483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Boehringer Ingelheim Vetmedica GmbH"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The benefits of pimobendan in the treatment of congestive heart failure (CHF) in cats with hypertrophic cardiomyopathy (HCM) have not been evaluated prospectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>To investigate the effects of pimobendan in cats with HCM and recent CHF and to identify possible endpoints for a pivotal study. We hypothesized that pimobendan would be well-tolerated and associated with improved outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Eighty-three cats with HCM and recently controlled CHF: 30 with and 53 without left ventricular outflow tract obstruction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective randomized placebo-controlled double-blind multicenter nonpivotal field study. Cats received either pimobendan (0.30\u2009mg\/kg q12h, n = 43), placebo (n = 39), or no medication (n = 1) together with furosemide (&amp;lt;10 mg\/kg\/d) with or without clopidogrel. The primary endpoint was a successful outcome (ie, completing the 180-day study period without a dose escalation of furosemide).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The proportion of cats in the full analysis set population with a successful outcome was not different between treatment groups (P = .75). For nonobstructive cats, the success rate was 32% in pimobendan-treated cats versus 18.2% in the placebo group (odds ratio [OR], 2.12; 95% confidence interval [CI], 0.54-8.34). For obstructive cats, the success rate was 28.6% and 60% in the pimobendan and placebo groups, respectively (OR, 0.27; 95% CI, 0.06-1.26). No difference was found between treatments for the secondary endpoints of time to furosemide dose escalation or death (P = .89). Results were similar in the per-protocol sets. Adverse events in both treatment groups were similar.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>In this study of cats with HCM and recent CHF, no benefit of pimobendan on 180-day outcome was identified.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16054","type":"journal-article","created":{"date-parts":[[2021,2,7]],"date-time":"2021-02-07T23:33:55Z","timestamp":1612740835000},"page":"789-800","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Effects of pimobendan in cats with hypertrophic cardiomyopathy and recent congestive heart failure: Results of a prospective, double-blind, randomized, nonpivotal, exploratory field study"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1286-0759","authenticated-orcid":false,"given":"Karsten E.","family":"Schober","sequence":"first","affiliation":[{"name":"The Ohio State University , Department of Veterinary Clinical Sciences, Columbus, Ohio,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8277-8996","authenticated-orcid":false,"given":"John E.","family":"Rush","sequence":"additional","affiliation":[{"name":"Cummings School of Veterinary Medicine, Tufts University , North Grafton, Massachusetts,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8076-3806","authenticated-orcid":false,"given":"Virginia","family":"Luis Fuentes","sequence":"additional","affiliation":[{"name":"Royal Veterinary College, Clinical Sciences and Services , London,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Glaus","sequence":"additional","affiliation":[{"name":"University of Z\u00fcrich, Clinic for Small Animal Internal Medicine , Z\u00fcrich,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuala J.","family":"Summerfield","sequence":"additional","affiliation":[{"name":"North Downs Specialist Referrals , Bletchingley,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7927-3145","authenticated-orcid":false,"given":"Kathy","family":"Wright","sequence":"additional","affiliation":[{"name":"MedVet , Cincinnati and Dayton, Ohio,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Lehmkuhl","sequence":"additional","affiliation":[{"name":"MedVet , Columbus, Ohio,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6634-8072","authenticated-orcid":false,"given":"Gerhard","family":"Wess","sequence":"additional","affiliation":[{"name":"University of Munich, Clinic of Small Animal Medicine , Munich,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret P.","family":"Sayer","sequence":"additional","affiliation":[{"name":"Charlotte Animal Referral & Emergency , Charlotte, North Carolina,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joao","family":"Loureiro","sequence":"additional","affiliation":[{"name":"North Downs Specialist Referrals , Bletchingley,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"MacGregor","sequence":"additional","affiliation":[{"name":"New England Veterinary Cardiology , Durham, North 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