{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T10:10:15Z","timestamp":1770286215160,"version":"3.49.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":1739,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T00:00:00Z","timestamp":1622073600000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Blood l-lactate concentrations are higher in people with developing or established diabetes mellitus and insulin resistance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate whether blood l-lactate concentrations are positively correlated with measures of insulin dysregulation (ID) or increased autumnal ACTH concentrations in ponies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Systemically healthy client-owned ponies (n = 101).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective case-control study. Blood samples were obtained from 101 clinically healthy ponies. Breed, weight, height, and subjective and objective measures of body condition were recorded. Blood l-lactate, glucose, triglyceride, total adiponectin, and ACTH concentrations were measured and an oral sugar test (OST) was carried out. Correlations between blood l-lactate and variables of endocrine health were determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Using a seasonal cutoff point of ACTH concentrations \u226547\u2009pg\/mL, 55 ponies had increased autumnal ACTH concentrations and 45 did not. Using a basal insulin concentration of &amp;gt;50\u2009\u03bciU\/mL, 42 ponies were diagnosed with ID and 58 were not. Using a 60\u2009minutes after OST cutoff point of &amp;gt;45\u2009\u03bciU\/mL, 57 ponies had ID and 37 did not. Blood l-lactate concentrations were significantly lower in obese (average body condition score\u2009\u2265\u20097\/9) compared to nonobese ponies (0.6\u2009mmol\/L; range, 0.0-1.9\u2009mmol\/L vs 0.8\u2009mmol\/L; range, 0.3-2.7\u2009mmol\/L; P = .01). No other significant correlations were detected. No differences were detected between ponies with and without increased autumnal ACTH concentrations (0.7\u2009mmol\/L; range, 0.0-2.7\u2009mmol\/L vs 0.7\u2009mmol\/L; range, 0.3-1.8\u2009mmol\/L; P = .84) and with and without ID (0.7\u2009mmol\/L; range, 0.3-2.7\u2009mmol\/L vs 0.8\u2009mmol\/L; range, 0.0-1.6\u2009mmol\/L; P = .63).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Results do not support an effect of endocrine status on l-lactate concentrations in blood of ponies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16079","type":"journal-article","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T14:24:58Z","timestamp":1622125498000},"page":"1582-1588","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Influence of endocrine disease on l-lactate 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