{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:07:15Z","timestamp":1791594435581,"version":"4.3.4"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":1800,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T00:00:00Z","timestamp":1614124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hypersomatotropism (HST) is an increasingly recognized endocrinopathy in cats and is mostly described associated with diabetes mellitus (DM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the efficacy and safety of transsphenoidal hypophysectomy in treating HST and DM in cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Sixty-eight client-owned cats with HST and DM treated by transsphenoidal hypophysectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective cohort study. Medical records were reviewed for glycemic control and serum insulin-like growth factor-1 (IGF-1) concentrations. Postoperative complications, death within 4\u2009weeks, and proportion achieving diabetic remission were recorded. Survival times and DM-free intervals were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty-eight cats (85.3%) were alive 4\u2009weeks postoperatively with 10 (15%) postoperative deaths. Complications included hypoglycemia (n = 9), electrolyte imbalance (n = 9), and transient congestive heart failure (n = 5). Fifty-five cats (95% of 58 surviving cats [81% of all cats undergoing surgery]) had improved control of diabetes. Diabetic remission occurred in 41 cats (71% of 58 surviving cats [60% of all cats]) with insulin administration discontinued after a median of 9\u2009days (range, 2-120). Postoperative 4-week serum IGF-1 concentration nadir was significantly lower in cats achieving diabetic remission (median 20\u2009ng\/mL [15-708] than those that did not (324\u2009ng\/mL [15-1955]; P = .03). All cats received long-term levothyroxine and hydrocortisone PO, alongside desmopressin (conjunctival) in 38 of 53 cats (72%). Recurrence of DM occurred in 5 of 41 cats (12%) after a median of 248\u2009days (range, 84-1232). Median survival time of all cats was 853\u2009days (range, 1-1740).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Transsphenoidal hypophysectomy is an effective treatment for cats with HST and DM, with a long-term outcome that compares favorably to existing options.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16080","type":"journal-article","created":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T08:10:58Z","timestamp":1614154258000},"page":"823-833","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Efficacy of hypophysectomy for the treatment of hypersomatotropism-induced diabetes mellitus in 68 cats"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7851-670X","authenticated-orcid":false,"given":"Joe","family":"Fenn","sequence":"first","affiliation":[{"name":"Royal Veterinary College Department of Clinical Science and Services, , Hatfield,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J.","family":"Kenny","sequence":"additional","affiliation":[{"name":"Small Animal Specialist Hospital , North Ryde, New South Wales,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9896-9893","authenticated-orcid":false,"given":"Christopher J.","family":"Scudder","sequence":"additional","affiliation":[{"name":"Southfields Veterinary Specialists , Laindon Essex,","place":["UK"]},{"name":"Royal Veterinary College Department of Comparative Biomedical Sciences, , London,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Hazuchova","sequence":"additional","affiliation":[{"name":"Royal Veterinary College Department of Clinical Science and Services, , Hatfield,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9354-8291","authenticated-orcid":false,"given":"Ruth","family":"Gostelow","sequence":"additional","affiliation":[{"name":"Royal Veterinary College Department of Clinical Science and Services, , Hatfield,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Fowkes","sequence":"additional","affiliation":[{"name":"Royal Veterinary College Department of Comparative Biomedical Sciences, , London,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaiza","family":"Forcada","sequence":"additional","affiliation":[{"name":"Royal Veterinary College Department of Clinical Science and Services, , Hatfield,","place":["UK"]},{"name":"The VetCT Telemedicine Hospital, VetCT, St. John's Innovation Centre , Cambridge,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Church","sequence":"additional","affiliation":[{"name":"Royal Veterinary College Department of Clinical Science and Services, , Hatfield,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stijn J. 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