{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T12:10:57Z","timestamp":1776082257155,"version":"3.50.1"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":1800,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,3,6]],"date-time":"2021-03-06T00:00:00Z","timestamp":1614988800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Point-of-care (POC) Coccidioides antibody assays may provide veterinarians with rapid and accurate diagnostic information.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine the agreement of a POC lateral flow assay (LFA), sona Coccidioides (IMMY, Norman, Oklahoma) with the current diagnostic standard, the immunodiffusion assay (agar gel immunodiffusion [AGID]; Coccidioidomycosis Serology Laboratory, University of California, Davis, California).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Forty-eight sera specimens from 48 dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sera specimens were collected from client-owned dogs that had a clinical suspicion for coccidioidomycosis. Animals were classified as Coccidioides antibody-positive (n = 36) based on a positive AGID or Coccidioides antibody-negative (n = 12) based on a negative AGID. The performance of the LFA assay was determined by comparing results to AGID results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The LFA assay demonstrated agreement in 32 of 36 Coccidioides antibody-positive specimens and 12 of 12 Coccidioides antibody-negative specimens, resulting in a positive percentage agreement of 88.9% (95% confidence interval [CI], 74.7-95.6%) and negative percentage agreement of 100% (95% CI, 75.8-100%) as compared to AGID. A receiver operator characteristic curve was constructed, and the area under the curve was 0.944 (CI, 0.880-1.000).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Clinical importance<\/jats:title>\n                    <jats:p>This LFA is a rapid alternative to the traditional AGID. The LFA provides excellent predictive value for positive results. Positive agreement was lower in dogs with low AGID titers; therefore, confirmatory testing is recommended if a high index of suspicion exists.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16087","type":"journal-article","created":{"date-parts":[[2021,3,6]],"date-time":"2021-03-06T04:54:02Z","timestamp":1615006442000},"page":"965-969","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Clinical performance of a point-of-care\n                    <i>Coccidioides<\/i>\n                    antibody test in dogs"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3426-6352","authenticated-orcid":false,"given":"Krystle L.","family":"Reagan","sequence":"first","affiliation":[{"name":"University of California-Davis Department of Medicine and Epidemiology, , Davis, California,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"McHardy","sequence":"additional","affiliation":[{"name":"University of California-Davis Department of Medical Microbiology and Immunology, , Davis, California,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"George R.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of California Davis Medical Center Department of Internal Medicine, , Sacramento, California,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane E.","family":"Sykes","sequence":"additional","affiliation":[{"name":"University of California-Davis Department of Medicine and Epidemiology, , Davis, California,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,3,1]]},"reference":[{"key":"2026020303060959700_jvim16087-bib-0001","first-page":"185","article-title":"Coccidioidomycosis: epidemiology","volume":"5","author":"Brown","year":"2013","journal-title":"Clin Epidemiol"},{"key":"2026020303060959700_jvim16087-bib-0002","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.2460\/javma.2005.226.1846","article-title":"Incidence of Coccidioides infection among dogs residing in a region in which the organism is endemic","volume":"226","author":"Shubitz","year":"2005","journal-title":"J Am Vet Med Assoc"},{"key":"2026020303060959700_jvim16087-bib-0003","doi-asserted-by":"crossref","first-page":"S67","DOI":"10.1093\/mmy\/myy113","article-title":"Selected clinical features of Coccidioidomycosis in dogs","volume":"57","author":"Davidson","year":"2019","journal-title":"Med 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