{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T15:49:04Z","timestamp":1774972144926,"version":"3.50.1"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":1739,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T00:00:00Z","timestamp":1616112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A 3-year-old spayed female English Springer Spaniel was presented twice 4\u2009months apart for investigation of hematuria and pollakiuria without urinary tract infection. Both ultrasound examinations identified a stable craniodorsal bladder wall thickening. The first cystoscopic biopsy samples indicated lymphoplasmacytic cystitis and the second polypoid cystitis. The dog was represented 8\u2009months later for recurrent clinical signs despite medical management. Although the ultrasound examination showed stable disease, repeat cystoscopic biopsy identified transitional cell carcinoma (TCC), confirmed on tissue removed by partial cystectomy. No BRAF mutation was ever detected in urine or tissue samples. To our knowledge, this case represents the first report of presumptive malignant transformation of polypoid cystitis into an apical TCC in a dog. Dogs with polypoid cystitis should be followed closely and surgical management considered if rapid resolution is not achieved with medical management.<\/jats:p>","DOI":"10.1111\/jvim.16107","type":"journal-article","created":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T06:23:57Z","timestamp":1616135037000},"page":"1551-1557","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Presumptive malignant transformation of chronic polypoid cystitis into an apical transitional cell carcinoma without BRAF mutation in a young female dog"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0797-3484","authenticated-orcid":false,"given":"Emmanuelle Marie","family":"Butty","sequence":"first","affiliation":[{"name":"Tufts University Cummings School of Veterinary Medicine, Internal Medicine , North Grafton, Massachusetts,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shelley","family":"Hahn","sequence":"additional","affiliation":[{"name":"Tufts University Cummings School of Veterinary Medicine, Internal Medicine , North Grafton, Massachusetts,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7871-2479","authenticated-orcid":false,"given":"Mary Anna","family":"Labato","sequence":"additional","affiliation":[{"name":"Tufts University Cummings School of Veterinary Medicine, Internal Medicine , North Grafton, Massachusetts,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,5,1]]},"reference":[{"key":"2026020303071104300_jvim16107-bib-0001","first-page":"533","article-title":"Pathology of Domestic Animals","author":"Jubb","year":"1993","edition":"5"},{"key":"2026020303071104300_jvim16107-bib-0002","first-page":"666","article-title":"Tumors in Domestic Animals","author":"Meuten Donald","year":"2017","edition":"5"},{"issue":"3","key":"2026020303071104300_jvim16107-bib-0003","first-page":"499","article-title":"Polypoid cystitis in 17 dogs (1978-2001)","volume":"17","author":"Martinez","year":"2003","journal-title":"J Vet Intern Med"},{"issue":"3","key":"2026020303071104300_jvim16107-bib-0004","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1292\/jvms.67.57","article-title":"Diagnostic ultrasound of polypoid cystitis in dogs","volume":"67","author":"Takiguchi","year":"2005","journal-title":"J Vet Med Sci"},{"issue":"3","key":"2026020303071104300_jvim16107-bib-0005","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.2460\/javma.1975.166.12.1155","article-title":"Canine polypoid cystitis","volume":"166","author":"Johnston","year":"1975","journal-title":"J Am Vet Med Assoc"},{"issue":"3","key":"2026020303071104300_jvim16107-bib-0006","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1292\/jvms.70.289","article-title":"Polypoid eosinophilic cystitis with pseudosarcomatous proliferative tissue in a dog","volume":"70","author":"Ozaki","year":"2008","journal-title":"J Vet Med Sci"},{"key":"2026020303071104300_jvim16107-bib-0007","first-page":"163","article-title":"A case of polypoid cystitis in a dog","volume":"49","author":"Im","year":"2009","journal-title":"Korean J Vet Res"},{"issue":"3","key":"2026020303071104300_jvim16107-bib-0008","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1177\/0300985809353176","article-title":"Urinary bladder mass in a dog","volume":"47","author":"Gelberg","year":"2010","journal-title":"Vet Pathol"},{"issue":"3","key":"2026020303071104300_jvim16107-bib-0009","doi-asserted-by":"crossref","first-page":"281","DOI":"10.5326\/0460281","article-title":"Surgical management of diffuse polypoid cystitis using submucosal resection in a dog","volume":"46","author":"Wolfe","year":"2010","journal-title":"J Am Anim Hosp Assoc"},{"issue":"3","key":"2026020303071104300_jvim16107-bib-0010","doi-asserted-by":"crossref","first-page":"414","DOI":"10.5326\/JAAHA-MS-6068","article-title":"Ultrasound-guided urinary bladder biopsy through a urinary catheter in a bitch","volume":"50","author":"Lopez","year":"2014","journal-title":"J Am Anim Hosp Assoc"},{"issue":"3","key":"2026020303071104300_jvim16107-bib-0011","first-page":"181","article-title":"Struvite urolithiasis with eosinophilic polypoid cystitis in a shih tzu dog","volume":"59","author":"Walker","year":"2018","journal-title":"Can Vet J"},{"issue":"3","key":"2026020303071104300_jvim16107-bib-0012","first-page":"179","article-title":"Polypoid cystitis. 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