{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:14:03Z","timestamp":1787494443771,"version":"build-2736575974"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":1739,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T00:00:00Z","timestamp":1617840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001808","name":"Commission for Technology and Innovation","doi-asserted-by":"crossref","award":["18288.1 PFLS-LS"],"award-info":[{"award-number":["18288.1 PFLS-LS"]}],"id":[{"id":"10.13039\/501100001808","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Measurement of serum concentrations of insulin-like growth factor (IGF)-1 is used to diagnose acromegaly in cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis<\/jats:title>\n                    <jats:p>Changes of body weight do not affect serum concentrations of IGF-1 in cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Ten healthy purpose-bred cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective study. In lean cats, food availability was stepwise increased during the first week and given ad libitum for a total of 40\u2009weeks to increase their body weight. From week 41 to week 60, food access was limited to reach a weight loss of 1% to 2% each week. Measurement of IGF-1 was performed at week 0, 16, 40, and 60. Insulin-like growth factor-1 was measured by radioimmunoassay. Body weight and IGF-1 were compared among the 4 time points.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Body weight increased by 44% from week 0 (4.5\u2009\u00b1\u20090.4 kg) to week 40 (6.5\u2009\u00b1\u20091.2 kg) (P\u2009&amp;lt;\u2009.001) and decreased by 25% from week 40 to week 60 (4.9\u2009\u00b1\u20090.7 kg) (P\u2009&amp;lt;\u2009.001). Serum IGF-1 concentrations did not differ during the study period (week 0, 16, 40, 60: 500\u2009\u00b1\u2009188, 479\u2009\u00b1\u2009247, 470\u2009\u00b1\u2009184, 435\u2009\u00b1\u2009154\u2009ng\/mL, respectively; P = .38). Correlations with body weight were not observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Insulin-like growth factor-1 might not be influenced by changes of body weight in healthy cats, possibly suggesting that the latter is unimportant when interpreting IGF-1 results in this species.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16119","type":"journal-article","created":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T07:39:59Z","timestamp":1617867599000},"page":"1274-1278","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Serum insulin-like growth factor-1 concentrations in healthy cats before and after weight gain and weight loss"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7580-1297","authenticated-orcid":false,"given":"Eric","family":"Zini","sequence":"first","affiliation":[{"name":"Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich , Zurich,","place":["Switzerland"]},{"name":"Production and Health, University of Padova Department of Animal Medicine, , Legnaro (PD),","place":["Italy"]},{"name":"AniCura Istituto Veterinario Novara , Granozzo con Monticello (NO),","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Salesov","sequence":"additional","affiliation":[{"name":"Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich , Zurich,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Willing","sequence":"additional","affiliation":[{"name":"Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich , Zurich,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2752-2613","authenticated-orcid":false,"given":"Carlo","family":"Palizzotto","sequence":"additional","affiliation":[{"name":"AniCura Istituto Veterinario Novara , Granozzo con Monticello (NO),","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Lutz","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Physiology, Vetsuisse Faculty, University of Zurich , Zurich,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia E.","family":"Reusch","sequence":"additional","affiliation":[{"name":"Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich , 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