{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T11:55:46Z","timestamp":1785239746416,"version":"3.55.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":1739,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,5,15]],"date-time":"2021-05-15T00:00:00Z","timestamp":1621036800000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hypercortisolism affects calcium and phosphate metabolism in dogs; however, the exact mechanisms are not completely understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate circulating concentrations of whole parathormone (wPTH), 25-hydroxyvitamin D (25-(OH)D), calcitriol, and fibroblast growth factor-23 (FGF-23) in dogs with naturally occurring hypercortisolism (NOHC) and healthy dogs, and their association with calcium and phosphate homeostasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Twenty-three client-owned dogs with NOHC, and 12 client or staff-owned healthy dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective cross-sectional study. The circulating concentrations of total calcium, ionized calcium (iCa), phosphate, wPTH, 25-(OH)D, calcitriol and FGF-23, and the urinary fractional excretion of phosphate (FEP) and calcium (FECa) were compared between dogs with NOHC before treatment and healthy dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Dogs with NOHC had higher mean serum phosphate concentrations (4.81\u2009mg\/dL, SD\u2009\u00b1\u20090.71 vs 3.86\u2009mg\/dL, SD\u2009\u00b1\u20090.60; P\u2009&amp;lt;\u2009.001), median FECa (0.43%, range, 0.03-2.44 vs 0.15%, range, 0.06-0.35; P = .005), and median serum wPTH concentrations (54.6 pg\/mL, range, 23.7-490 vs 24.6\u2009pg\/mL, range, 5.5-56.4; P = .003) as compared to the controls. Circulating concentrations of total calcium, iCa, and calcitriol and the FEP did not differ between groups, whereas the serum 25-(OH)D concentrations were lower in dogs with NOHC as compared to the controls (70.2 pg\/mL, SD\u2009\u00b1\u200942.3 vs 106.3\u2009pg\/mL, SD\u2009\u00b1\u200935.3; P = .02). The dogs with NOHC had lower plasma FGF-23 concentrations than controls (316.6 pg\/mL, range, 120.8-575.6 vs 448.7\u2009pg\/mL, range, 244.8-753; P = .03).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Urine loss of calcium and hyperphosphatemia could contribute to the adrenal secondary hyperparathyroidism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16143","type":"journal-article","created":{"date-parts":[[2021,5,15]],"date-time":"2021-05-15T05:39:05Z","timestamp":1621057145000},"page":"1265-1273","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Calcium and phosphate homeostasis in dogs with newly diagnosed naturally occurring hypercortisolism"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1673-8715","authenticated-orcid":false,"given":"Andrea","family":"Corsini","sequence":"first","affiliation":[{"name":"Alma Mater Studiorum-University of Bologna Department of Veterinary Medical Sciences, , Ozzano Emilia,","place":["Italy"]},{"name":"University of Parma Department of Veterinary Medical Sciences, , Parma,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8259-6458","authenticated-orcid":false,"given":"Francesco","family":"Dondi","sequence":"additional","affiliation":[{"name":"Alma Mater Studiorum-University of Bologna Department of Veterinary Medical Sciences, , Ozzano Emilia,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria G.","family":"Serio","sequence":"additional","affiliation":[{"name":"Alma Mater Studiorum-University of Bologna Department of Veterinary Medical Sciences, , Ozzano Emilia,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Zamagni","sequence":"additional","affiliation":[{"name":"Alma Mater Studiorum-University of Bologna Department of Veterinary Medical Sciences, , Ozzano Emilia,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Golinelli","sequence":"additional","affiliation":[{"name":"Alma Mater Studiorum-University of Bologna Department of Veterinary Medical Sciences, , Ozzano Emilia,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Alma Mater Studiorum-University of Bologna Department of Veterinary Medical Sciences, , Ozzano Emilia,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3121-2199","authenticated-orcid":false,"given":"Federico","family":"Fracassi","sequence":"additional","affiliation":[{"name":"Alma Mater Studiorum-University of Bologna Department of Veterinary Medical Sciences, , Ozzano Emilia,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,5,1]]},"reference":[{"key":"2026020303082028500_jvim16143-bib-0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.tvjl.2019.105342","article-title":"Diagnosis of spontaneous hyperadrenocorticism in dogs. 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