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Increased vascularization contributes to the thickening of the bronchial wall in humans with asthma and is considered a potential new therapeutic target.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the presence of angiogenesis in the bronchi of severely asthmatic horses, and if present, to evaluate its reversibility by treatment with corticosteroids.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Study 1: Bronchial samples from asthmatic horses in exacerbation (7), in remission (7), and aged-matched healthy horses. Study 2: Endobronchial biopsy samples from asthmatic horses in exacerbation (6) and healthy horses (6) before and after treatment with dexamethasone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Blinded, randomized controlled study. Immunohistochemistry was performed using collagen IV as a marker for vascular basement membranes. Number of vessels, vascular area, and mean vessel size in the bronchial lamina propria were measured by histomorphometry. Reversibility of vascular changes in Study 2 was assessed after 2\u2009weeks of treatment with dexamethasone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The number of vessels and vascular area were increased in the airway walls of asthmatic horses in exacerbation (P\u00a0=\u00a0.01 and P\u00a0=\u00a0.02, respectively) and in remission (P\u00a0=\u00a0.02 and P\u00a0=\u00a0.04, respectively) when compared to controls. In Study 2, the differences observed between groups disappeared after 2\u2009weeks of treatment with corticosteroids because of the increased number of vessels in healthy horses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Angiogenesis contributes to thickening of the airway wall in asthmatic horses and was not reversed by a 2-week treatment with corticosteroids.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16159","type":"journal-article","created":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T09:10:01Z","timestamp":1622193001000},"page":"2026-2034","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Bronchial angiogenesis in horses with severe asthma and its response to 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