{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:39:38Z","timestamp":1770745178639,"version":"3.49.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":1678,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T00:00:00Z","timestamp":1621209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is limited published information on the outcome for cats where total thyroxine concentration (TT4) remains elevated after treatment with radioactive iodine (RAI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the frequency of, and predictors for, subsequent treatment failure in cats for which TT4 remains elevated at hospital discharge, and to report clinical outcomes for cats requiring repeat treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>One hundred twenty-one cats with TT4 \u226540\u2009nmol\/L after treatment with RAI (out of an original, treated study sample of 959 cats).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective study. Data regarding signalment, weight, TT4 concentration (before RAI treatment, at discharge, and percentage change), day of sampling, and I-131 dose were acquired. Logistic regression was performed to evaluate predictors of treatment failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the 87 cats for which classification was possible, 35 (40%) became euthyroid without further treatment. All TT4 variables and weight normalized RAI dose were independently predictive of subsequent treatment failure. In multivariate analysis, TT4 concentration at discharge (P\u2009&amp;lt;\u2009.001) and weight normalized RAI dose (P\u00a0=\u00a0.04) remained in the final model. All 28 cats with TT4 concentration \u2265150\u2009nmol\/L at discharge ultimately failed treatment, compared with 13\/40 (32.5%) and 11\/19 (57.9%) cats with TT4 concentrations of 40-100\u2009nmol\/L and 100-150\u2009nmol\/L, respectively. Of the 52 cats that failed treatment, 14 were subsequently managed medically, 12 underwent thyroidectomy (4 with carcinoma), 14 had repeat RAI treatment which was successful in 12\/14 (86%) cats, and 13 had no further treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Cats with TT4 &amp;gt;150\u2009nmol\/L at discharge after RAI might be candidates for immediate repeat treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16161","type":"journal-article","created":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T13:11:52Z","timestamp":1621257112000},"page":"1688-1696","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Treatment failure in hyperthyroid cats after radioiodine (I-131) injection"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6470-5910","authenticated-orcid":false,"given":"Deirdre","family":"Mullowney","sequence":"first","affiliation":[{"name":"Royal Veterinary College, University of London Department of Veterinary Clinical Sciences, , Hertfordshire AL9 7TA,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Mei","family":"Chang","sequence":"additional","affiliation":[{"name":"Research Support Office, The Royal Veterinary College , London,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Glanemann","sequence":"additional","affiliation":[{"name":"Royal Veterinary College, University of London Department of Veterinary Clinical Sciences, , Hertfordshire AL9 7TA,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harriet 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