{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:39:29Z","timestamp":1770745169325,"version":"3.49.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":1678,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T00:00:00Z","timestamp":1621209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005361","name":"American College of Veterinary Internal Medicine Foundation","doi-asserted-by":"publisher","award":["15-11 ZOETIS"],"award-info":[{"award-number":["15-11 ZOETIS"]}],"id":[{"id":"10.13039\/100005361","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005361","name":"American College of Veterinary Internal Medicine Foundation","doi-asserted-by":"publisher","award":["15\u201011 ZOETIS"],"award-info":[{"award-number":["15\u201011 ZOETIS"]}],"id":[{"id":"10.13039\/100005361","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Laryngeal paralysis commonly affects older Labrador retrievers. Currently, dogs with severe disease require surgical intervention, most commonly arytenoid lateralization. Anecdotally, doxepin has been proposed to help dogs with laryngeal paralysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis<\/jats:title>\n                    <jats:p>Doxepin will improve quality of life measures assessed by owners of Labrador retrievers with laryngeal paralysis not requiring emergency surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Twenty-two Labrador retrievers with laryngeal paralysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Dogs were randomized to receive doxepin (3-5\u00a0mg\/kg q12h PO) or placebo for 28\u2009days. Owners completed quality-of-life assessments before and after completing the study. Data were compared between groups using Rank-Sum tests or Fisher's exact tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The 2 groups of dogs did not differ at baseline except for owner-perceived degree of ataxia (owners of dogs receiving doxepin considered them more ataxic than owners of dogs receiving placebo). After 28\u2009days, owner-assessed quality of life measures did not differ between dogs receiving doxepin or placebo (dogs worsening: doxepin\u00a0=\u00a02, placebo\u00a0=\u00a01; dogs unchanged: doxepin\u00a0=\u00a06, placebo\u00a0=\u00a07; dogs improved: doxepin\u00a0=\u00a04, placebo\u00a0=\u00a02; P\u00a0=\u00a0.84). Dogs receiving placebo had a greater improvement in client-assessed overall health than dogs receiving doxepin (mean ranks: doxepin\u00a0=\u00a04.36, placebo\u00a0=\u00a06.64; P\u00a0=\u00a0.04). The study was terminated at this interim analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Doxepin did not appear to improve any measures of owner-assessed quality of life in Labrador retrievers with laryngeal paralysis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16162","type":"journal-article","created":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T07:15:50Z","timestamp":1621235750000},"page":"1943-1949","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of doxepin on quality of life in Labradors with laryngeal paralysis: A double-blinded, randomized, placebo-controlled trial"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0477-1780","authenticated-orcid":false,"given":"Mark","family":"Rishniw","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, Cornell University Department of Clinical Sciences, , Ithaca, New York,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill","family":"Sammarco","sequence":"additional","affiliation":[{"name":"Red Bank Veterinary Hospital , Tinton Falls, New Jersey,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric N.","family":"Glass","sequence":"additional","affiliation":[{"name":"Red Bank Veterinary Hospital , Tinton Falls, New Jersey,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brittany","family":"Cerroni","sequence":"additional","affiliation":[{"name":"Gulf Coast Veterinary Specialists , Houston, Texas,","place":["USA"]},{"name":"Brittany Cerroni, Hope Veterinary Specialists , Malvern, PA,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,7,1]]},"reference":[{"issue":"4","key":"2026020922180286500_jvim16162-bib-0001","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1111\/j.1751-0813.2003.tb13361.x","article-title":"A retrospective study of unilateral arytenoid lateralisation in the treatment of laryngeal paralysis in 100 dogs (1992\u20132000)","volume":"81","author":"Snelling","year":"2003","journal-title":"Australian Veterinary Journal"},{"key":"2026020922180286500_jvim16162-bib-0002","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.2460\/javma.228.8.1215","article-title":"Postoperative results of unilateral arytenoid lateralization for treatment of idiopathic laryngeal paralysis in dogs: 39 cases (1996-2002)","volume":"228","author":"Hammel","year":"2006","journal-title":"J Am Vet Med Assoc"},{"key":"2026020922180286500_jvim16162-bib-0003","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/j.1532-950X.2007.00302.x","article-title":"Bilateral thyroarytenoid cartilage lateralization and vocal fold excision with mucosoplasty for treatment of idiopathic laryngeal paralysis: 67 dogs (1998-2005)","volume":"36","author":"Schofield","year":"2007","journal-title":"Vet Surg"},{"issue":"4","key":"2026020922180286500_jvim16162-bib-0004","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.2460\/javma.2001.218.1949","article-title":"Outcome of and postoperative complications in dogs undergoing surgical treatment of laryngeal paralysis: 140 cases (1985-1998)","volume":"218","author":"MacPhail","year":"2001","journal-title":"J Am Vet Med Assoc"},{"key":"2026020922180286500_jvim16162-bib-0005","doi-asserted-by":"crossref","first-page":"377","DOI":"10.2460\/javma.1985.186.04.377","article-title":"Laryngeal paralysis in dogs: a review of 23 cases","volume":"186","author":"Gaber","year":"1985","journal-title":"J Am Vet Med Assoc"},{"issue":"4","key":"2026020922180286500_jvim16162-bib-0006","article-title":"Laryngeal paralysis in dogs: An update on recent knowledge","volume":"84","author":"Kitshoff","year":"2013","journal-title":"Journal of the South African Veterinary Association"},{"issue":"4","key":"2026020922180286500_jvim16162-bib-0007","doi-asserted-by":"crossref","first-page":"161","DOI":"10.5326\/0460161","article-title":"Histopathological Confirmation of Polyneuropathy in 11 Dogs With Laryngeal Paralysis","volume":"46","author":"Thieman","year":"2010","journal-title":"Journal of the American Animal Hospital Association"},{"key":"2026020922180286500_jvim16162-bib-0008","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/vms3.240","article-title":"Late-onset laryngeal paralysis: owner perception of quality of life and cause of death","volume":"6","author":"Sample","year":"2020","journal-title":"Vet Med Sci"},{"key":"2026020922180286500_jvim16162-bib-0009","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/vr.105120","article-title":"Outcome of two variations of a surgical technique performed for canine unilateral arytenoid lateralisation","volume":"185","author":"Perez Lopez","year":"2019","journal-title":"Vet Rec"},{"key":"2026020922180286500_jvim16162-bib-0010","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.rvsc.2017.12.007","article-title":"Evaluation of Translaryngeal Percutaneous Arytenoid Lateralization (TPAL) in dogs with experimentally created laryngeal paralysis","volume":"117","author":"Sample","year":"2018","journal-title":"Res Vet Sci"},{"issue":"4","key":"2026020922180286500_jvim16162-bib-0011","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/j.cvsm.2016.02.003","article-title":"Surgical Treatment of Laryngeal Paralysis","volume":"46","author":"Monnet","year":"2016","journal-title":"Veterinary Clinics of North America: Small Animal Practice"},{"key":"2026020922180286500_jvim16162-bib-0012","doi-asserted-by":"crossref","first-page":"188","DOI":"10.2460\/javma.248.2.188","article-title":"Risk factors for the development of aspiration pneumonia after unilateral arytenoid lateralization in dogs with laryngeal paralysis: 232 cases (1987\u20132012)","volume":"248","author":"Wilson","year":"2016","journal-title":"J Am Vet Med Assoc"},{"key":"2026020922180286500_jvim16162-bib-0013","doi-asserted-by":"crossref","first-page":"241","DOI":"10.5326\/0460241","article-title":"Intraoperative evaluation of the larynx following unilateral arytenoid lateralization for acquired idiopathic laryngeal paralysis in dogs","volume":"46","author":"Weinstein","year":"2010","journal-title":"J Am Anim Hosp Assoc"},{"key":"2026020922180286500_jvim16162-bib-0014","first-page":"212","article-title":"Laryngeal paralysis in dogs","volume":"31","author":"Millard","year":"2009","journal-title":"Compend Contin Educ Vet"},{"key":"2026020922180286500_jvim16162-bib-0015","article-title":"Doxepin [Internet]. Stat Pearls. 2020","author":"Almasi"},{"key":"2026020922180286500_jvim16162-bib-0016","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/j.1740-8261.2001.tb00949.x","article-title":"The role of ultrasound in the assessment of laryngeal paralysis in the dog","volume":"42","author":"Rudorf","year":"2001","journal-title":"Vet Radiol Ultrasound"},{"key":"2026020922180286500_jvim16162-bib-0017","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/0197-2456(90)90005-M","article-title":"Power and sample size calculations. A review and computer program","volume":"11","author":"Dupont","year":"1990","journal-title":"Control Clin Trials"},{"key":"2026020922180286500_jvim16162-bib-0018","first-page":"1","article-title":"PAST: paleontological statistics software package for education and data analysis","volume":"4","author":"Hammer","year":"2001","journal-title":"Paleontol Electron"},{"key":"2026020922180286500_jvim16162-bib-0019","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.2460\/javma.241.10.1314","article-title":"Caregiver placebo effect for dogs with lameness from osteoarthritis","volume":"241","author":"Conzemius","year":"2012","journal-title":"J Am Vet Med Assoc"},{"key":"2026020922180286500_jvim16162-bib-0020","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/vsu.13110","article-title":"Comparison of methohexital and propofol as induction agents for evaluation of laryngeal function in healthy dogs","volume":"48","author":"Brown","year":"2019","journal-title":"Vet Surg"},{"key":"2026020922180286500_jvim16162-bib-0021","doi-asserted-by":"crossref","first-page":"19","DOI":"10.5326\/JAAHA-MS-5959","article-title":"Comparison of propofol and propofol\/ketamine anesthesia for evaluation of laryngeal function in healthy dogs","volume":"50","author":"McKeirnan","year":"2014","journal-title":"J Am Anim Hosp Assoc"},{"key":"2026020922180286500_jvim16162-bib-0022","first-page":"791","article-title":"Effects of alfaxalone, thiopental, or propofol and diazepam on laryngeal motion in healthy dogs","volume":"59","author":"Ambros","year":"2018","journal-title":"Can Vet J"}],"container-title":["Journal of Veterinary Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvim.16162","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jvim.16162","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jvim\/article-pdf\/35\/4\/1943\/66652691\/jvim16162.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jvim\/article-pdf\/35\/4\/1943\/66652691\/jvim16162.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T03:29:50Z","timestamp":1770694190000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jvim\/article\/35\/4\/1943\/8447047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,1]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,7,1]]}},"URL":"https:\/\/doi.org\/10.1111\/jvim.16162","relation":{},"ISSN":["1939-1676"],"issn-type":[{"value":"1939-1676","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,7]]},"published":{"date-parts":[[2021,7,1]]},"assertion":[{"value":"2020-12-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}