{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:39:36Z","timestamp":1770745176951,"version":"3.49.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":1678,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T00:00:00Z","timestamp":1622678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Apart from the absence of nociception, there is no readily available prognostic test for dogs presenting with paraplegia secondary to acute intervertebral disc extrusion (IVDE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess if serum C-reactive protein (CRP) can predict the postoperative outcome in paraplegic dogs undergoing surgery for IVDE and to assess the association between serum CRP and presence\/absence of nociception on admission, and serum CRP and presence\/absence of intramedullary changes seen on magnetic resonance imaging (MRI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>One hundred dogs that underwent surgery at our hospital between 2018 and 2020 because of acute paraplegia secondary to IVDE and in which serum CRP was measured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective observational cohort study. Dogs were classified as 4 or 5 according to the modified Frankel score (MFS) depending on presence\/absence of nociception, respectively. MRI images were reviewed and the T2-weighted hyperintensity: L2 vertebral body length was measured. Postoperative outcome was defined as positive if nociception, ambulation or both returned after decompressive surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median (95% CI) serum CRP was 4 (4-5) and 6 (4-7) mg\/L in MSF4 and MSF5, respectively (P\u00a0=\u00a0.03). A weak linear relationship (R2\u00a0=\u00a00.049, P\u00a0=\u00a0.03) was found between CRP and the T2-weighted hyperintensity: L2 vertebral length. Outcome data was available for 85 dogs: CRP was 4 (4-5) and 5 (4-10) mg\/L in positive and negative outcome dogs, respectively (P\u00a0=\u00a0.32).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Clinical Importance<\/jats:title>\n                    <jats:p>Serum CRP did not predict outcome after surgery in dogs with paraplegia secondary to IVDE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16179","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T08:56:37Z","timestamp":1622796997000},"page":"1857-1864","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Serum C-reactive protein in dogs with paraplegia secondary to acute intervertebral disc extrusion"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2381-1389","authenticated-orcid":false,"given":"Max","family":"Foreman","sequence":"first","affiliation":[{"name":"Dick White Referrals , Cambs,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enzo","family":"Vettorato","sequence":"additional","affiliation":[{"name":"Dick White Referrals , Cambs,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abby","family":"Caine","sequence":"additional","affiliation":[{"name":"Dick White Referrals , Cambs,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Monti","sequence":"additional","affiliation":[{"name":"Dick White Referrals , Cambs,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giunio Bruto","family":"Cherubini","sequence":"additional","affiliation":[{"name":"Dick White Referrals , Cambs,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salih","family":"Eminaga","sequence":"additional","affiliation":[{"name":"Dick White Referrals , Cambs,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,7,1]]},"reference":[{"key":"2026020922172528900_jvim16179-bib-0001","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1111\/j.1748-5827.1997.tb03303.x","article-title":"Hemilaminectomy for the treatment of thoracolumbar disc disease in the dog: a follow-up studv of 40 cases","volume":"38","author":"Scott","year":"1997","journal-title":"J Small Anim Pract"},{"key":"2026020922172528900_jvim16179-bib-0002","doi-asserted-by":"crossref","first-page":"762","DOI":"10.2460\/javma.2003.222.762","article-title":"Long-term functional outcome of dogs with severe injuries of the thoracolumbar spinal cord: 87 cases (1996\u20132001)","volume":"222","author":"Olby","year":"2003","journal-title":"J Am Vet Med Assoc"},{"key":"2026020922172528900_jvim16179-bib-0003","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1111\/jvim.15439","article-title":"Time course and prognostic value of serum GFAP, pNFH, and S100\u03b2 concentrations in dogs with complete spinal cord injury because of intervertebral disc extrusion","volume":"33","author":"Olby","year":"2019","journal-title":"J Vet Intern Med"},{"key":"2026020922172528900_jvim16179-bib-0004","doi-asserted-by":"crossref","first-page":"386","DOI":"10.2460\/javma.248.4.386","article-title":"Factors associated with recovery from paraplegia in dogs with loss of pain perception in the pelvic limbs following intervertebral disk herniation","volume":"248","author":"Jeffery","year":"2016","journal-title":"J Am Vet Med Assoc"},{"key":"2026020922172528900_jvim16179-bib-0005","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1439-0442.2005.00698.x","article-title":"Duration and severity of clinical signs as prognostic indicators in 30 dogs with thoracolumbar disk disease after surgical decompression","volume":"52","author":"Kazakos","year":"2005","journal-title":"J Vet Med Ser"},{"key":"2026020922172528900_jvim16179-bib-0006","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1532-950X.2014.12144.x","article-title":"Evaluation of serum phosphorylated neurofilament subunit NF-H as a prognostic biomarker in dogs with thoracolumbar intervertebral disc herniation","volume":"43","author":"Nishida","year":"2014","journal-title":"Vet Surg"},{"key":"2026020922172528900_jvim16179-bib-0007","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1292\/jvms.12-0483","article-title":"Serum glial fibrillary acidic protein as a diagnostic biomarker in dogs with progressive myelomalacia","volume":"75","author":"Sato","year":"2013","journal-title":"J Vet Med Sci"},{"key":"2026020922172528900_jvim16179-bib-0008","doi-asserted-by":"crossref","first-page":"555","DOI":"10.2460\/javma.240.5.555","article-title":"Associations between cerebrospinal fluid biomarkers and long-term neurologic outcome in dogs with acute intervertebral disk herniation","volume":"240","author":"Witsberger","year":"2012","journal-title":"J Am Vet Med Assoc"},{"key":"2026020922172528900_jvim16179-bib-0009","doi-asserted-by":"crossref","first-page":"283","DOI":"10.2460\/ajvr.67.2.283","article-title":"Matrix metalloproteinase-9 activity in the cerebrospinal fluid and serum of dogs with acute spinal cord trauma from intervertebral disk disease","volume":"67","author":"Levine","year":"2006","journal-title":"Am J Vet Res"},{"key":"2026020922172528900_jvim16179-bib-0010","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.tvjl.2013.02.005","article-title":"Cerebrospinal fluid tau protein as a biomarker for severity of spinal cord injury in dogs with intervertebral disc herniation","volume":"197","author":"Roerig","year":"2013","journal-title":"Vet J"},{"key":"2026020922172528900_jvim16179-bib-0011","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.2460\/javma.2005.227.1454","article-title":"Prognostic value of magnetic resonance imaging in dogs with paraplegia caused by thoracolumbar intervertebral disk extrusion: 77 cases (2000-2003)","volume":"227","author":"Ito","year":"2005","journal-title":"J Am Vet Med Assoc"},{"key":"2026020922172528900_jvim16179-bib-0012","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/jvim.14656","article-title":"Prevalence and risk factors for presumptive ascending\/descending myelomalacia in dogs after thoracolumbar intervertebral disk herniation","volume":"31","author":"Balducci","year":"2017","journal-title":"J Vet Intern Med"},{"key":"2026020922172528900_jvim16179-bib-0013","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1939-165X.2005.tb00019.x","article-title":"Acute phase proteins in dogs and cats: current knowledge and future perspectives","volume":"34","author":"Cer\u00f3n","year":"2005","journal-title":"Vet Clin Path"},{"key":"2026020922172528900_jvim16179-bib-0014","doi-asserted-by":"crossref","first-page":"386","DOI":"10.3171\/jns.1988.69.3.0386","article-title":"Mechanisms and implications of hypoalbuminemia in head-injured patients","volume":"69","author":"McClain","year":"1988","journal-title":"J Neurosurg"},{"key":"2026020922172528900_jvim16179-bib-0015","doi-asserted-by":"crossref","first-page":"375","DOI":"10.3171\/jns.1988.69.3.0375","article-title":"The acute-phase response of the brain-injured patient","volume":"69","author":"Young","year":"1988","journal-title":"J Neurosurg"},{"key":"2026020922172528900_jvim16179-bib-0016","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1007\/s001340050837","article-title":"Correlation between serum IL-6 and CRP levels and severity of head injury in children","volume":"25","author":"Kalabalikis","year":"1999","journal-title":"Intensiv Care Med"},{"key":"2026020922172528900_jvim16179-bib-0017","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1258\/002367700780387679","article-title":"C-reactive protein (CRP) measurement in canine serum following experimentally-induced acute gastric mucosal injury","volume":"34","author":"Otabe","year":"2000","journal-title":"Lab Anim"},{"key":"2026020922172528900_jvim16179-bib-0018","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1939-1676.2003.tb02450.x","article-title":"A scoring index for disease activity in canine inflammatory bowel disease","volume":"17","author":"Jergens","year":"2003","journal-title":"J Vet Intern Med"},{"key":"2026020922172528900_jvim16179-bib-0019","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/BF00638925","article-title":"Acute phase proteins as markers of inflammatory lesions","volume":"5","author":"Eckersall","year":"1995","journal-title":"Comp Haematol Int"},{"key":"2026020922172528900_jvim16179-bib-0020","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1534-6935.2004.04010.x","article-title":"C-reactive protein concentrations in canine acute pancreatitis","volume":"14","author":"Holm","year":"2004","journal-title":"J Vet Emerg Crit Care"},{"key":"2026020922172528900_jvim16179-bib-0021","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1292\/jvms.68.1275","article-title":"C-reactive protein concentration in canine idiopathic polyarthritis","volume":"68","author":"Ohno","year":"2006","journal-title":"J Vet Med Sci"},{"key":"2026020922172528900_jvim16179-bib-0022","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1111\/jvim.14787","article-title":"Serum thymidine kinase 1, canine C-reactive protein, haptoglobin, and vitamin D concentrations in dogs with immune-mediated hemolytic anemia, thrombocytopenia, and polyarthropathy","volume":"31","author":"Grobman","year":"2017","journal-title":"J Vet Intern Med"},{"key":"2026020922172528900_jvim16179-bib-0023","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/BF01839236","article-title":"Changes in serum C-reactive protein levels in dogs with various disorders and surgical traumas","volume":"17","author":"Yamamoto","year":"1993","journal-title":"Vet Res Commun"},{"key":"2026020922172528900_jvim16179-bib-0024","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1080\/01652176.1994.9694422","article-title":"Determination of C-reactive protein in serum and plasma from healthy dogs and dogs with pneumonia by ELISA and slide reversed passive latex agglutination test","volume":"16","author":"Yamamoto","year":"1994","journal-title":"Vet Q"},{"key":"2026020922172528900_jvim16179-bib-0025","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/vde.12510","article-title":"Evaluation of C-reactive protein as an inflammatory marker of pemphigus foliaceus and superficial pyoderma in dogs","volume":"29","author":"Severo","year":"2018","journal-title":"Vet Dermatol"},{"key":"2026020922172528900_jvim16179-bib-0026","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/vec.12685","article-title":"Inflammatory cytokine and C-reactive protein concentrations in dogs with systemic inflammatory response syndrome","volume":"28","author":"Gommeren","year":"2018","journal-title":"J Vet Emerg Crit Care"},{"key":"2026020922172528900_jvim16179-bib-0027","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1111\/jvim.13954","article-title":"Thymidine kinase type 1 and C-reactive protein concentrations in dogs with spontaneously occurring cancer","volume":"30","author":"Selting","year":"2016","journal-title":"J Vet Intern Med"},{"key":"2026020922172528900_jvim16179-bib-0028","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1023\/A:1015290903332","article-title":"Monitoring C-reactive protein in beagle dogs experimentally inoculated with Ehrlichia canis","volume":"26","author":"Shimada","year":"2002","journal-title":"Vet Res Commun"},{"key":"2026020922172528900_jvim16179-bib-0029","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.2460\/ajvr.2003.64.1021","article-title":"Serum concentrations of acute-phase proteins in dogs with leishmaniosis during short-term treatment","volume":"64","author":"Martinez-Subiela","year":"2003","journal-title":"Am J Vet Res"},{"key":"2026020922172528900_jvim16179-bib-0030","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.tvjl.2008.05.001","article-title":"The role of acute phase proteins in diagnosis and management of steroid-responsive meningitis arteritis in dogs","volume":"182","author":"Lowrie","year":"2009","journal-title":"Vet J"},{"key":"2026020922172528900_jvim16179-bib-0031","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/jsap.12418","article-title":"Relapses in dogs with steroid-responsive meningitis-arteritis","volume":"57","author":"Biedermann","year":"2016","journal-title":"J Small Anim Pract"},{"key":"2026020922172528900_jvim16179-bib-0032","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1111\/j.1939-1676.2008.0164.x","article-title":"Concentrations of acute-phase proteins in dogs with steroid responsive meningitis-arteritis","volume":"22","author":"Bathen-Noethen","year":"2008","journal-title":"J Vet Intern Med"},{"key":"2026020922172528900_jvim16179-bib-0033","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1292\/jvms.70.127","article-title":"C-reactive protein concentration in dogs with various diseases","volume":"70","author":"Nakamura","year":"2008","journal-title":"J Vet Med Sci"},{"key":"2026020922172528900_jvim16179-bib-0034","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12917-015-0628-x","article-title":"Measurements of C-reactive protein (CRP) and nerve-growth-factor (NGF) concentrations in serum and urine samples of dogs with neurologic disorders","volume":"12","author":"Kordass","year":"2016","journal-title":"BMC Vet Res"},{"key":"2026020922172528900_jvim16179-bib-0035","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1089\/neu.2015.3895","article-title":"Acute phase proteins in cerebrospinal fluid from dogs with naturally-occurring spinal cord injury","volume":"32","author":"Anderson","year":"2015","journal-title":"J Neurotrauma"},{"key":"2026020922172528900_jvim16179-bib-0036","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/sc.1969.30","article-title":"The value of postural reduction in the initial management of closed injuries of the spine with paraplegia and tetraplegia","volume":"7","author":"Frankel","year":"1969","journal-title":"Spinal Cord"},{"key":"2026020922172528900_jvim16179-bib-0037","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/vcp.12150","article-title":"Validation of a commercially available automated canine-specific immunoturbidimetric method for measuring canine C-reactive protein","volume":"43","author":"Hillstr\u00f6m","year":"2014","journal-title":"Vet Clin Pathol"},{"key":"2026020922172528900_jvim16179-bib-0038","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/jsap.12979","article-title":"Low-field magnetic resonance changes in the paravertebral musculature of dogs with acute intervertebral disc extrusion","volume":"60","author":"Furtado","year":"2019","journal-title":"J Small Anim Pract"},{"key":"2026020922172528900_jvim16179-bib-0039","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3389\/fvets.2018.00016","article-title":"Magnetic resonance imaging signal alterations in paraspinal muscles in dogs with acute thoracolumbar intervertebral disk extrusion","volume":"5","author":"Trampus","year":"2018","journal-title":"Front Vet Sci"},{"key":"2026020922172528900_jvim16179-bib-0040","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.pneurobio.2013.11.002","article-title":"From basics to clinical: a comprehensive review on spinal cord injury","volume":"114","author":"Silva","year":"2014","journal-title":"Prog Neurobiol"},{"key":"2026020922172528900_jvim16179-bib-0041","doi-asserted-by":"crossref","first-page":"754","DOI":"10.3389\/fimmu.2018.00754","article-title":"Role of C-reactive protein at sites of inflammation and infection","volume":"9","author":"Sproston","year":"2018","journal-title":"Front Immunol"},{"key":"2026020922172528900_jvim16179-bib-0042","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1089\/neu.2013.3034","article-title":"Characterization of vascular disruption and blood\u2013spinal cord barrier permeability following traumatic spinal cord injury","volume":"31","author":"Figley","year":"2014","journal-title":"J Neurotrauma"},{"key":"2026020922172528900_jvim16179-bib-0043","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1740-8261.2010.01746.x","article-title":"Clinical, pathologic, and magnetic resonance imaging characteristics of canine disc extrusion accompanied by epidural hemorrhage or inflammation","volume":"52","author":"Mateo","year":"2011","journal-title":"Vet Radiol Ultrasound"},{"key":"2026020922172528900_jvim16179-bib-0044","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1111\/jvim.12095","article-title":"Clinical and pathological analysis of epidural inflammation in intervertebral disk extrusion in dogs","volume":"27","author":"Fadda","year":"2013","journal-title":"J Vet Intern Med"},{"key":"2026020922172528900_jvim16179-bib-0045","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1172\/JCI18921C1","article-title":"C-reactive protein: a critical update","volume":"112","author":"Pepys","year":"2003","journal-title":"J Clin Invest"},{"key":"2026020922172528900_jvim16179-bib-0046","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1159\/000097202","article-title":"Passage of cytokines across the blood-brain barrier","volume":"2","author":"Banks","year":"1995","journal-title":"Neuroimmunomodulation"},{"key":"2026020922172528900_jvim16179-bib-0047","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1111\/j.1939-1676.2009.0393.x","article-title":"Magnetic resonance imaging in dogs with neurologic impairment due to acute thoracic and lumbar intervertebral disk herniation","volume":"23","author":"Levine","year":"2009","journal-title":"J Vet Intern Med"},{"key":"2026020922172528900_jvim16179-bib-0048","doi-asserted-by":"crossref","first-page":"E81","DOI":"10.1097\/BSD.0b013e31823f2f55","article-title":"Quantitative magnetic resonance imaging characteristics","volume":"25","author":"Boekhoff","year":"2012","journal-title":"J Spinal Disord Tech"},{"key":"2026020922172528900_jvim16179-bib-0049","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/BF01839386","article-title":"Creatine kinase in the dog: a review","volume":"17","author":"Aktas","year":"1993","journal-title":"Vet Res Commun"},{"key":"2026020922172528900_jvim16179-bib-0050","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1939-1676.2000.tb01496.x","article-title":"Gastric mucosal lesions in dogs with acute intervertebral disc disease: characterization and effects of omeprazole or misoprostol","volume":"14","author":"Neiger","year":"2000","journal-title":"J Vet Intern Med"},{"key":"2026020922172528900_jvim16179-bib-0051","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/jsap.12818","article-title":"Canine pancreatic lipase immunoreactivity concentrations associated with intervertebral disc disease in 84 dogs","volume":"59","author":"Schueler","year":"2018","journal-title":"J Small Anim Pract"},{"key":"2026020922172528900_jvim16179-bib-0052","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1111\/j.1939-1676.2011.0729.x","article-title":"Biological variability of c-reactive protein and specific canine pancreatic lipase immunoreactivity in apparently healthy dogs","volume":"25","author":"Carney","year":"2011","journal-title":"J Vet Intern Med"}],"container-title":["Journal of Veterinary Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvim.16179","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jvim.16179","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jvim\/article-pdf\/35\/4\/1857\/66652020\/jvim16179.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jvim\/article-pdf\/35\/4\/1857\/66652020\/jvim16179.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T03:28:00Z","timestamp":1770694080000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jvim\/article\/35\/4\/1857\/8446980"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,1]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,7,1]]}},"URL":"https:\/\/doi.org\/10.1111\/jvim.16179","relation":{},"ISSN":["1939-1676"],"issn-type":[{"value":"1939-1676","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,7]]},"published":{"date-parts":[[2021,7,1]]},"assertion":[{"value":"2020-12-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}