{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:02:49Z","timestamp":1787162569703,"version":"build-2736575974"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":1616,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T00:00:00Z","timestamp":1628812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Downer cow syndrome, a common problem in dairy cattle, represents a diagnostic and therapeutic challenge for the attending veterinarian. Identifying prognostic indicators and assessing the odds of survival may improve the accuracy of the clinician's prognosis at the time of diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe a population of downer dairy cows referred to a hospital and investigate predictors of outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Recumbent adult dairy cows (cows unable or unwilling to stand without help) treated at a referral hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data at the time of admission were collected from medical records of downer dairy cows treated at the Centre Hospitalier Universitaire V\u00e9t\u00e9rinaire between 1994 and 2016. Simple and multivariable logistic regression analyses were performed to assess the association of predictors with the outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 1318 cows included, 727 (55%) cows were discharged, and 591 (45%) cows died or were euthanized. Cows with longer time of recumbency before referral (odds ratio [OR] = 3.6), tachycardia (100-120 beats per minute [bpm], OR\u00a0=\u00a01.93; &amp;gt;120\u2009bpm, OR\u00a0=\u00a02.92), tachypnea (OR\u00a0=\u00a01.76), hypothermia (OR\u00a0=\u00a02.08), anemia (OR\u00a0=\u00a03.30), neutropenia (OR\u00a0=\u00a01.7), high aspartate aminotransferase activity (500-1000\u2009U\/L, OR\u00a0=\u00a02.16; &amp;gt;1000\u2009U\/L, OR\u00a0=\u00a06.69), and increased serum creatinine concentration (OR\u00a0=\u00a01.75) had higher odds of nonsurvival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>These findings may help the practitioner to consider treatment options and decide if referral is likely beneficial based on the odds of success. Early recognition of low chance of survival may facilitate an early decision for euthanasia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16249","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T07:12:32Z","timestamp":1628838752000},"page":"2534-2543","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Survival and prognostic indicators in downer dairy cows presented to a referring hospital: A retrospective study (1318 cases)"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7230-6848","authenticated-orcid":false,"given":"Maria","family":"Puerto-Parada","sequence":"first","affiliation":[{"name":"D\u00e9partement de Sciences Cliniques, Facult\u00e9 de M\u00e9decine V\u00e9t\u00e9rinaire, Universit\u00e9 de Montr\u00e9al , Saint-Hyacinthe, QC J2S 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8H5,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Nichols","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Sciences Cliniques, Facult\u00e9 de M\u00e9decine V\u00e9t\u00e9rinaire, Universit\u00e9 de Montr\u00e9al , Saint-Hyacinthe, QC J2S 8H5,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Babkine","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Sciences Cliniques, Facult\u00e9 de M\u00e9decine V\u00e9t\u00e9rinaire, Universit\u00e9 de Montr\u00e9al , Saint-Hyacinthe, QC J2S 8H5,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Arango-Sabogal","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Sciences Cliniques, Facult\u00e9 de M\u00e9decine V\u00e9t\u00e9rinaire, Universit\u00e9 de Montr\u00e9al , Saint-Hyacinthe, QC J2S 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