{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:17:55Z","timestamp":1791267475411,"version":"4.1.0"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":1616,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K01-OD019912"],"award-info":[{"award-number":["K01-OD019912"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K01\u2010OD019912"],"award-info":[{"award-number":["K01\u2010OD019912"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Medical dissolution of struvite uroliths in dogs is commonly recommended, but data on success rates and complications are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the efficacy of medical dissolution for suspected struvite cystoliths in dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Fifty client-owned dogs fed a therapeutic dissolution diet, with or without administration of antimicrobials, for treatment of suspected struvite cystoliths.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Single institution, retrospective case series. Medical records were reviewed for dogs with at least 1 follow-up visit. Dissolution success, complications, and possible predictors of success were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Full dissolution of cystoliths was achieved in 58% (29\/50) of dogs within a median of 35\u2009days (range, 13-167). Of 21 dogs without success, 7 each had partial dissolution, no dissolution, or undetermined outcome. Uroliths containing &amp;gt;10% nonstruvite mineral were common in the nonsuccess group (11\/16 analyzed). Maximum urolith diameter, number of uroliths, and baseline urine pH did not differ significantly between dogs with and without success. Dissolution was more likely in dogs receiving antimicrobial therapy (OR\u00a0=\u00a016.3, 95% confidence interval 1.9-787.4, P\u00a0=\u00a0.002). Adverse events occurred in 9 dogs (18%); urethral obstructions were the most common, but 3 of 4 dogs with this complication were obstructed on presentation, before trial initiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Results support a medical dissolution trial for dogs with suspected struvite cystoliths. If no reduction in urolith size or number occurs by 1\u00a0month, a nonstruvite composition is likely, and alternative interventions should be considered. Dogs presenting with urethral obstructions should not be considered candidates for medical dissolution.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16252","type":"journal-article","created":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T09:05:16Z","timestamp":1630487116000},"page":"2287-2295","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy of medical dissolution for suspected struvite cystoliths in dogs"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1500-8307","authenticated-orcid":false,"given":"Allie M.","family":"Wingert","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, University of Minnesota Department of Veterinary Clinical Sciences, , St. Paul, Minnesota,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia A.","family":"Murray","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, University of Minnesota Department of Veterinary Clinical Sciences, , St. Paul, Minnesota,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2338-1569","authenticated-orcid":false,"given":"Jody P.","family":"Lulich","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, University of Minnesota Department of Veterinary Clinical Sciences, , St. Paul, Minnesota,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis M.","family":"Hoelmer","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, University of Minnesota Department of Veterinary Clinical Sciences, , St. Paul, Minnesota,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay K.","family":"Merkel","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, University of Minnesota Department of Veterinary Clinical Sciences, , St. Paul, Minnesota,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7339-2354","authenticated-orcid":false,"given":"Eva","family":"Furrow","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, University of Minnesota Department of Veterinary Clinical Sciences, , St. Paul, Minnesota,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,9,1]]},"reference":[{"key":"2026020303475817200_jvim16252-bib-0001","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2460\/javma.236.2.193","article-title":"Evaluation of trends in urolith composition and characteristics of dogs with urolithiasis: 25,499 cases (1985-2006)","volume":"236","author":"Low","year":"2010","journal-title":"J Am Vet Med Assoc"},{"key":"2026020303475817200_jvim16252-bib-0002","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1136\/vr.101056","article-title":"Recent shifts in the global proportions of canine uroliths","volume":"172","author":"Lulich","year":"2013","journal-title":"Vet Rec"},{"key":"2026020303475817200_jvim16252-bib-0003","first-page":"45","article-title":"Analysis of canine urolith submissions to the Canadian Veterinary Urolith Centre, 1998-2014","volume":"58","author":"Houston","year":"2017","journal-title":"Can Vet J"},{"key":"2026020303475817200_jvim16252-bib-0004","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1111\/jvim.14559","article-title":"ACVIM small animal consensus recommendations on the treatment and prevention of uroliths in dogs and cats","volume":"30","author":"Lulich","year":"2016","journal-title":"J Vet Intern Med"},{"key":"2026020303475817200_jvim16252-bib-0005","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0195-5616(99)50006-5","article-title":"Medical dissolution and prevention of canine struvite urolithiasis. 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