{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T11:44:10Z","timestamp":1781869450481,"version":"3.54.5"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":1572,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T00:00:00Z","timestamp":1634774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Dechra Products Ltd"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The use of adrenocorticotropic hormone stimulation test as method to monitor efficacy of trilostane treatment of hypercortisolism (HC) in dogs has been questioned.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate and compare 12 methods with which to monitor efficacy of trilostane treatment in dogs with HC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Forty-five client-owned dogs with HC treated with trilostane q12h.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective cross-sectional observational study. The dogs were categorized as well-controlled, undercontrolled, and unwell through a clinical score obtained from an owner questionnaire. The ability to correctly identify trilostane-treatment control of dogs with HC with the following variables was evaluated: before trilostane serum cortisol (prepill), before-ACTH serum cortisol, post-ACTH serum cortisol, plasma endogenous ACTH concentrations, prepill\/eACTH ratio, serum haptoglobin (Hp) concentration, serum alanine aminotransferase (ALT), gamma-glutamyl transferase (\u03b3GT) and alkaline phosphatase activity, urine specific gravity, and urinary cortisol\u00a0:\u00a0creatinine ratio.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ninety-four re-evaluations of 44 dogs were included; 5 re-evaluations of 5 unwell dogs were excluded. Haptoglobin was significantly associated with the clinical score (P\u2009&amp;lt;\u2009.001) and in the receiver operating characteristic analysis, Hp cutoff of 151\u2009mg\/dL correctly identified 90.0% of well-controlled dogs (specificity) and 65.6% of undercontrolled dogs (sensitivity). Alanine aminotransferase (P\u00a0=\u00a0.01) and \u03b3GT (P\u00a0=\u00a0.009) were significantly higher in undercontrolled dogs. Cutoff of ALT and \u03b3GT greater than or equal to 86\u2009U\/L and 5.8\u00a0U\/L, respectively, were significantly associated with poor control of HC by trilostane.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Of all the 12 variables, Hp, and to a lesser degree ALT and \u03b3GT, could be considered additional tools to the clinical picture to identify well-controlled and undercontrolled trilostane-treated dogs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16269","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T10:49:31Z","timestamp":1634813371000},"page":"2616-2627","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Comparison of methods to monitor dogs with hypercortisolism treated with trilostane"],"prefix":"10.1093","volume":"35","author":[{"given":"Stefania","family":"Golinelli","sequence":"first","affiliation":[{"name":"University of Bologna Department of Veterinary Medical Science, , Bologna,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviani","family":"de Marco","sequence":"additional","affiliation":[{"name":"Naya Especialidades , Sao Paulo,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2463-4062","authenticated-orcid":false,"given":"Rodolfo Oliveira","family":"Leal","sequence":"additional","affiliation":[{"name":"CIISA \u2013 Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon , Lisbon,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7742-4229","authenticated-orcid":false,"given":"Andrea","family":"Barbarossa","sequence":"additional","affiliation":[{"name":"University of Bologna Department of Veterinary Medical Science, , Bologna,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Aniballi","sequence":"additional","affiliation":[{"name":"University of Bologna Department of Veterinary Medical Science, , Bologna,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Maietti","sequence":"additional","affiliation":[{"name":"University of Bologna Department of Biomedical and Neuromotor Sciences, , Bologna,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Maria","family":"Tardo","sequence":"additional","affiliation":[{"name":"University of Bologna Department of 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