{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:32:41Z","timestamp":1792096361009,"version":"4.4.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":1494,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T00:00:00Z","timestamp":1638489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"University of Buenos Aires-UBACyT","award":["20720170100006BA"],"award-info":[{"award-number":["20720170100006BA"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A 13-year-old Labrador retriever was diagnosed with Cushing's syndrome (CS) caused by primary bilateral nodular adrenocortical hyperplasia with adrenocorticotropic hormone (ACTH) expression. The pituitary origin of CS was ruled out by suppression of plasma ACTH concentration and absence of a proliferative lesion on histological evaluation of the pituitary gland using periodic acid-Schiff (PAS) staining, reticulin staining, and immunostaining for ACTH. A pheochromocytoma also was found at necropsy examination. On histological evaluation of both adrenal glands, at the junction of the fascicular and glomerular zones, multiple cell clusters distributed in both hyperplastic adrenal cortices expressed ACTH, whereas the pheochromocytoma cells did not. These results indicate that a disease similar to primary bilateral macronodular adrenocortical hyperplasia in humans also occurs in dogs, with intra-adrenocortical expression of ACTH, glucocorticoids excess, and clinical signs of CS. Therefore, the term ACTH-independent could be inappropriate in some cases of bilateral adrenocortical hyperplasia and suppressed plasma ACTH concentration in dogs.<\/jats:p>","DOI":"10.1111\/jvim.16320","type":"journal-article","created":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T03:55:09Z","timestamp":1638503709000},"page":"264-271","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cushing's syndrome caused by intra-adrenocortical adrenocorticotropic hormone in a dog"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6658-4748","authenticated-orcid":false,"given":"Elber A.","family":"Soler Arias","sequence":"first","affiliation":[{"name":"Universidad de Buenos Aires, Facultad de Ciencias Veterinarias, C\u00e1tedra de Cl\u00ednica M\u00e9dica de Peque\u00f1os Animales, Hospital Escuela de Medicina Veterinaria-U. Endocrinolog\u00eda , Ciudad Aut\u00f3noma de Buenos Aires,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8250-8665","authenticated-orcid":false,"given":"V\u00edctor A.","family":"Castillo","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires, Facultad de Ciencias Veterinarias, C\u00e1tedra de Cl\u00ednica M\u00e9dica de Peque\u00f1os Animales, Hospital Escuela de Medicina Veterinaria-U. Endocrinolog\u00eda , Ciudad Aut\u00f3noma de Buenos Aires,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4723-095X","authenticated-orcid":false,"given":"Estelle","family":"Louiset","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNIROUEN, INSERM, DC2N , Rouen,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6181-9648","authenticated-orcid":false,"given":"Herve","family":"Lefebvre","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNIROUEN, INSERM, DC2N , Rouen,","place":["France"]},{"name":"Diabetes and Metabolic Diseases, University Hospital of Rouen Department of Endocrinology, , 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