{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T13:32:13Z","timestamp":1792416733657,"version":"4.4.0"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":1494,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T00:00:00Z","timestamp":1637798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Despite multiple reports of chemotherapy overdoses (ODs) in human and veterinary medicine, anthracycline ODs have been described infrequently.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>Describe toxicities, treatments, and overall outcome after anthracycline OD in dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Twelve mitoxantrone (MTX) and 4 doxorubicin (DOX) ODs were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Multicenter retrospective analysis. The American College of Veterinary Internal Medicine oncology and internal medicine listservs were solicited for cases in which a chemotherapy OD occurred.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixteen anthracycline cases were collected. Anthracycline ODs occurred because of an error in chemotherapy preparation (n\u00a0=\u00a09), or dose miscalculation (n\u00a0=\u00a07). The overall median OD was 1.9\u00d7 (range, 1.4-10\u00d7) the prescribed amount. Most ODs were identified immediately after drug administration (n\u00a0=\u00a011), and the majority of patients were hospitalized on supportive care (n\u00a0=\u00a011) for an average of 8\u2009days (range, 3-34\u2009days). Adverse events after the OD included neutropenia (94%), thrombocytopenia (88%), anemia (63%), diarrhea (63%), anorexia (56%), vomiting (38%), lethargy (31%), and nausea (25%). Two patients did not survive the OD. High grade neutropenia was common and did not appear to be mitigated by the administration of filgrastim.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>All patients received supportive care after identifying the OD and death was uncommon. Further evaluation is needed to determine ideal therapeutic guidelines anthracycline OD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16325","type":"journal-article","created":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T06:40:10Z","timestamp":1637908810000},"page":"234-243","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Toxicity, outcome, and management of anthracycline overdoses in 16 dogs"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7074-1379","authenticated-orcid":false,"given":"Haylie C.","family":"Lawson","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, Iowa State University , Ames, Iowa,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4350-0614","authenticated-orcid":false,"given":"Margaret L.","family":"Musser","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Iowa State University , Ames, Iowa,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Regan","sequence":"additional","affiliation":[{"name":"SAGE Veterinary Centers , Campbell, California,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antony S.","family":"Moore","sequence":"additional","affiliation":[{"name":"Veterinary Oncology Consultants , Lake Innes, New South Wales,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Hohenhaus","sequence":"additional","affiliation":[{"name":"Animal Medical Center , New York, New York,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2459-7054","authenticated-orcid":false,"given":"Brian","family":"Flesner","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, University of Missouri , Columbia, Missouri,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad M.","family":"Johannes","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Iowa State University , Ames, Iowa,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,1,1]]},"reference":[{"key":"2026020303505281300_jvim16325-bib-0001","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1188\/14.CJON.18-04AP","article-title":"Development of a policy and procedure for accidental chemotherapy overdose","volume":"18","author":"Nelson","year":"2014","journal-title":"Clin J Oncol Nurs"},{"key":"2026020303505281300_jvim16325-bib-0002","first-page":"1079","article-title":"Successful management of doxorubicin overdose and extravasation in a dog with lymphoma","volume":"59","author":"Kicenuik","year":"2018","journal-title":"Can Vet J"},{"key":"2026020303505281300_jvim16325-bib-0003","first-page":"48","article-title":"Accidental doxorubicin overdose in a dog","volume":"46","author":"Birnie","year":"2016","journal-title":"Austral Vet Pract"},{"key":"2026020303505281300_jvim16325-bib-0004","doi-asserted-by":"crossref","first-page":"230","DOI":"10.5326\/JAAHA-MS-6411","article-title":"Recovery from cyclophosphamide overdose in a dog","volume":"53","author":"Finlay","year":"2017","journal-title":"J Am Anim Hosp Assoc"},{"key":"2026020303505281300_jvim16325-bib-0005","doi-asserted-by":"crossref","first-page":"222","DOI":"10.2460\/javma.245.2.222","article-title":"Cyclophosphamide intoxication because of pharmacy error in two dogs","volume":"245","author":"Wells","year":"2014","journal-title":"J Am Vet Med Assoc"},{"key":"2026020303505281300_jvim16325-bib-0006","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1748-5827.2009.00864.x","article-title":"Toxicities and salvage therapy following overdose of vinblastine in a cat","volume":"51","author":"Grant","year":"2010","journal-title":"J Small Anim Pract"},{"key":"2026020303505281300_jvim16325-bib-0007","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/vcp.12734","article-title":"Hemorrhagic diathesis and bone marrow aplasia secondary to lomustine overdose in a dog","volume":"48","author":"Henker","year":"2019","journal-title":"Vet Clin Pathol"},{"key":"2026020303505281300_jvim16325-bib-0008","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/vec.12719","article-title":"Use of charcoal hemoperfusion and hemodialysis in the treatment of methotrexate toxicosis in a dog","volume":"28","author":"Pardo","year":"2018","journal-title":"J Vet Emerg Crit Care (San Antonio)"},{"key":"2026020303505281300_jvim16325-bib-0009","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/j.1476-4431.2012.00783.x","article-title":"Accidental and experimentally induced 5-fluorouracil toxicity in dogs","volume":"22","author":"Sayre","year":"2012","journal-title":"J Vet Emerg Crit Care (San Antonio)"},{"key":"2026020303505281300_jvim16325-bib-0010","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.2460\/javma.1991.198.09.1618","article-title":"Efficacy of mitoxantrone against various neoplasms in dogs","volume":"198","author":"Ogilvie","year":"1991","journal-title":"J Am Vet Med Assoc"},{"key":"2026020303505281300_jvim16325-bib-0011","first-page":"271","article-title":"Comparison of efficacy and toxicity of doxorubicin and mitoxantrone in combination chemotherapy for canine lymphoma","volume":"57","author":"Wang","year":"2016","journal-title":"Can Vet J"},{"key":"2026020303505281300_jvim16325-bib-0012","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.2460\/javma.1994.204.12.1903","article-title":"Evaluation of mitoxantrone for the treatment of lymphoma in dogs","volume":"204","author":"Moore","year":"1994","journal-title":"J Am Vet Med Assoc"},{"key":"2026020303505281300_jvim16325-bib-0013","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1186\/s12917-018-1688-5","article-title":"Retrospective analysis of doxorubicin and prednisone as first-line therapy for canine B-cell lymphoma","volume":"14","author":"Al-Nadaf","year":"2018","journal-title":"BMC Vet Res"},{"key":"2026020303505281300_jvim16325-bib-0014","doi-asserted-by":"crossref","first-page":"533","DOI":"10.3109\/02841869509094021","article-title":"Accidental doxorubicin overdosage","volume":"34","author":"Back","year":"1995","journal-title":"Acta Oncol"},{"key":"2026020303505281300_jvim16325-bib-0015","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.2460\/javma.1991.198.09.1613","article-title":"Toxicoses associated with administration of mitoxantrone to dogs with malignant tumors","volume":"198","author":"Ogilvie","year":"1991","journal-title":"J Am Vet Med Assoc"},{"key":"2026020303505281300_jvim16325-bib-0016","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.2460\/javma.1989.195.11.1584","article-title":"Acute and short-term toxicoses associated with the administration of doxorubicin to dogs with malignant tumors","volume":"195","author":"Ogilvie","year":"1989","journal-title":"J Am Vet Med Assoc"},{"key":"2026020303505281300_jvim16325-bib-0017","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/BF02985161","article-title":"Accidental overdose of mitoxantrone in three patients","volume":"6","author":"Siegert","year":"1989","journal-title":"Med Oncol Tumor Pharmacother"},{"key":"2026020303505281300_jvim16325-bib-0018","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3109\/08880019309016526","article-title":"Reversible cardiopathy after accidental overdose of mitoxantrone","volume":"10","author":"Hachimi-Idrissi","year":"1993","journal-title":"Pediatr Hematol Oncol"},{"key":"2026020303505281300_jvim16325-bib-0019","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/vco.283","article-title":"Common terminology criteria for adverse events (VCOG-CTCAE) following chemotherapy or biological antineoplastic therapy in dogs and cats v1.1","volume":"14","author":"Veterinary Cooperative Oncology Group","year":"2016","journal-title":"Vet Comp Oncol"},{"key":"2026020303505281300_jvim16325-bib-0020","doi-asserted-by":"crossref","first-page":"570","DOI":"10.2460\/javma.1994.205.04.570","article-title":"Toxicoses associated with the administration of mitoxantrone to dogs with malignant tumors: a dose escalation study","volume":"205","author":"Ogilvie","year":"1994","journal-title":"J Am Vet Med Assoc"},{"key":"2026020303505281300_jvim16325-bib-0021","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1111\/jvim.15414","article-title":"Incidence and risk factors associated with development of clinical cardiotoxicity in dogs receiving doxorubicin","volume":"33","author":"Hallman","year":"2019","journal-title":"J Vet Intern Med"},{"key":"2026020303505281300_jvim16325-bib-0022","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S0195-5616(90)50040-6","article-title":"Toxicology of oncologic drugs","volume":"20","author":"O'Keefe","year":"1990","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"2026020303505281300_jvim16325-bib-0023","first-page":"1139","article-title":"Safety assessment of a new anticancer compound, mitoxantrone, in beagle dogs: comparison with doxorubicin. I. Clinical observations","volume":"66","author":"Henderson","year":"1982","journal-title":"Cancer Treat Rep"},{"key":"2026020303505281300_jvim16325-bib-0024","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1172\/JCI115049","article-title":"Chronic neutropenia. A new canine model induced by human granulocyte colony-stimulating factor","volume":"87","author":"Hammond","year":"1991","journal-title":"J Clin Invest"},{"key":"2026020303505281300_jvim16325-bib-0025","article-title":"The Merck Manual of Diagnosis and Therapy","author":"Ensley","year":"2021"},{"key":"2026020303505281300_jvim16325-bib-0026","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/vec.12729","article-title":"Treatment of carprofen overdose with therapeutic plasma exchange in a dog","volume":"28","author":"Kjaergaard","year":"2018","journal-title":"J Vet Emerg Crit Care (San Antonio)"},{"key":"2026020303505281300_jvim16325-bib-0027","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1111\/vec.12607","article-title":"Treatment of meloxicam overdose in a dog via therapeutic plasma exchange","volume":"27","author":"Walton","year":"2017","journal-title":"J Vet Emerg Crit Care (San Antonio)"},{"key":"2026020303505281300_jvim16325-bib-0028","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1002\/pbc.20284","article-title":"A case of vinblastine overdose managed with plasma exchange","volume":"45","author":"Spiller","year":"2005","journal-title":"Pediatr Blood Cancer"},{"key":"2026020303505281300_jvim16325-bib-0029","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/802312","article-title":"Successful treatment of Cisplatin overdose with plasma exchange","volume":"2010","author":"Yamada","year":"2010","journal-title":"Case Rep Med"},{"key":"2026020303505281300_jvim16325-bib-0030","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/BF00401450","article-title":"Pharmacological disposition of 1,4-dihydroxy-5-8-bis[[2[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride in the dog","volume":"13","author":"Lu","year":"1984","journal-title":"Cancer Chemother Pharmacol"},{"key":"2026020303505281300_jvim16325-bib-0031","first-page":"3417","article-title":"Plasma pharmacokinetics of adriamycin and adriamycinol: implications for the design of in vitro experiments and treatment protocols","volume":"43","author":"Greene","year":"1983","journal-title":"Cancer Res"},{"key":"2026020303505281300_jvim16325-bib-0032","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.2460\/ajvr.1994.55.11.1587","article-title":"Comparison of body surface area-based and weight-based dosage protocols for doxorubicin administration in dogs","volume":"55","author":"Arrington","year":"1994","journal-title":"Am J Vet Res"},{"key":"2026020303505281300_jvim16325-bib-0033","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/sdi.12228","article-title":"A stepwise approach for the management of poisoning with extracorporeal treatments","volume":"27","author":"Ghannoum","year":"2014","journal-title":"Semin Dial"},{"key":"2026020303505281300_jvim16325-bib-0034","first-page":"143","article-title":"Chemotherapy-induced diarrhea: options for treatment and prevention","volume":"2","author":"Koselke","year":"2012","journal-title":"J Hematol Oncol Pharm"},{"key":"2026020303505281300_jvim16325-bib-0035","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/pbc.21491","article-title":"Activated charcoal to prevent irinotecan-induced diarrhea in children","volume":"51","author":"Sergio","year":"2008","journal-title":"Pediatr Blood Cancer"},{"key":"2026020303505281300_jvim16325-bib-0036","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/bs.pmbts.2020.04.002","article-title":"Gut microbiota in reductive drug metabolism","volume":"171","author":"Guo","year":"2020","journal-title":"Prog Mol Biol Transl Sci"},{"key":"2026020303505281300_jvim16325-bib-0037","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/hon.2189","article-title":"Aminocaproic acid use in hospitalized patients with hematological malignancy: a case series","volume":"34","author":"Marshall","year":"2016","journal-title":"Hematol Oncol"},{"key":"2026020303505281300_jvim16325-bib-0038","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1111\/vox.12549","article-title":"Successful treatment of bleeding with tranexamic acid in a series of 12 patients with immune thrombocytopenia","volume":"112","author":"Mayer","year":"2017","journal-title":"Vox Sang"},{"key":"2026020303505281300_jvim16325-bib-0039","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1001\/archinte.1989.00390090039008","article-title":"Control of bleeding in patients with immune and nonimmune thrombocytopenia with aminocaproic acid","volume":"149","author":"Bartholomew","year":"1989","journal-title":"Arch Intern Med"},{"key":"2026020303505281300_jvim16325-bib-0040","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1186\/s13063-019-3663-2","article-title":"The TREATT Trial (TRial to EvaluAte Tranexamic acid therapy in Thrombocytopenia): safety and efficacy of tranexamic acid in patients with haematological malignancies with severe thrombocytopenia: study protocol for a double-blind randomised controlled trial","volume":"20","author":"Estcourt","year":"2019","journal-title":"Trials"},{"key":"2026020303505281300_jvim16325-bib-0041","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.2460\/ajvr.79.10.1057","article-title":"Pharmacokinetics of tranexamic acid in healthy dogs and assessment of its antifibrinolytic properties in canine blood","volume":"79","author":"Osekavage","year":"2018","journal-title":"Am J Vet Res"},{"key":"2026020303505281300_jvim16325-bib-0042","doi-asserted-by":"crossref","first-page":"305","DOI":"10.17236\/sat00160","article-title":"Effect of tranexamic acid on intra- and postoperative haemorrhage in dogs with surgically treated hemoperitoneum","volume":"160","author":"Sigrist","year":"2018","journal-title":"Schweiz Arch Tierheilkd"},{"key":"2026020303505281300_jvim16325-bib-0043","doi-asserted-by":"crossref","first-page":"144","DOI":"10.5326\/JAAHA-MS-6298","article-title":"Retrospective study of 122 dogs that were treated with the antifibrinolytic drug aminocaproic acid: 2010-2012","volume":"52","author":"Davis","year":"2016","journal-title":"J Am Anim Hosp Assoc"},{"key":"2026020303505281300_jvim16325-bib-0044","doi-asserted-by":"crossref","first-page":"731","DOI":"10.2165\/00003495-199448050-00007","article-title":"A review of its pharmacological properties and therapeutic efficacy in neutropenia","volume":"48","author":"Frampton","year":"1994","journal-title":"Drugs"},{"key":"2026020303505281300_jvim16325-bib-0045","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1056\/NEJM199107183250305","article-title":"Reduction by granulocyte colony-stimulating factor of fever and neutropenia induced by chemotherapy in patients with small-cell lung cancer","volume":"325","author":"Crawford","year":"1991","journal-title":"N Engl J Med"},{"key":"2026020303505281300_jvim16325-bib-0046","doi-asserted-by":"crossref","first-page":"79","DOI":"10.4103\/0971-5851.73590","article-title":"Granulocyte colony-stimulating factor (filgrastim) in chemotherapy-induced febrile neutropenia","volume":"31","author":"Advani","year":"2010","journal-title":"Indian J Med Paediatr Oncol"},{"key":"2026020303505281300_jvim16325-bib-0047","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD003189.pub2","article-title":"Granulopoiesis-stimulating factors to prevent adverse effects in the treatment of malignant lymphoma","volume":"1","author":"Bohlius","year":"2004","journal-title":"Cochrane Database Syst Rev"},{"key":"2026020303505281300_jvim16325-bib-0048","article-title":"Prophylactic antibiotics or G(M)-CSF for the prevention of infections and improvement of survival in cancer patients receiving myelotoxic chemotherapy","volume":"12","author":"Skoetz","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"2026020303505281300_jvim16325-bib-0049","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1939-1676.1992.tb00985.x","article-title":"Use of recombinant canine granulocyte colony-stimulating factor to decrease myelosuppression associated with the administration of mitoxantrone in the dog","volume":"6","author":"Ogilvie","year":"1992","journal-title":"J Vet Intern Med"},{"key":"2026020303505281300_jvim16325-bib-0050","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1097\/01.coc.0000217816.16236.22","article-title":"Same day pegfilgrastim and CHOP chemotherapy for non-Hodgkin lymphoma","volume":"29","author":"Lokich","year":"2006","journal-title":"Am J Clin Oncol"},{"key":"2026020303505281300_jvim16325-bib-0051","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1200\/JOP.091094","article-title":"Pegfilgrastim on the same day versus next day of chemotherapy in patients with breast cancer, non-small-cell lung cancer, ovarian cancer, and non-Hodgkin's lymphoma: results of four multicenter, double-blind, randomized phase II studies","volume":"6","author":"Burris","year":"2010","journal-title":"J Oncol Pract"},{"key":"2026020303505281300_jvim16325-bib-0052","article-title":"Neupogen (Filgrastim) Package Insert","author":"Amgen","year":"2012"},{"key":"2026020303505281300_jvim16325-bib-0053","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/vco.12406","article-title":"Antibiotic prophylaxis in veterinary cancer chemotherapy: a review and recommendations","volume":"16","author":"Bisson","year":"2018","journal-title":"Vet Comp Oncol"},{"key":"2026020303505281300_jvim16325-bib-0054","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1200\/JCO.19.02856","article-title":"Effect of dexrazoxane on left ventricular systolic function and treatment outcomes in patients with acute myeloid leukemia: a report from the Children's Oncology Group","volume":"38","author":"Getz","year":"2020","journal-title":"J Clin Oncol"}],"container-title":["Journal of Veterinary Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvim.16325","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jvim.16325","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jvim\/article-pdf\/36\/1\/234\/66665203\/jvim16325.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jvim\/article-pdf\/36\/1\/234\/66665203\/jvim16325.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T08:51:06Z","timestamp":1770108666000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jvim\/article\/36\/1\/234\/8448911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,1]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1,1]]}},"URL":"https:\/\/doi.org\/10.1111\/jvim.16325","relation":{},"ISSN":["1939-1676"],"issn-type":[{"value":"1939-1676","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,1]]},"published":{"date-parts":[[2022,1,1]]},"assertion":[{"value":"2021-06-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}