{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:19:34Z","timestamp":1789690774722,"version":"4.0.1"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":1494,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T00:00:00Z","timestamp":1638921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2015-04092"],"award-info":[{"award-number":["RGPIN-2015-04092"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN\u20102015\u201004092"],"award-info":[{"award-number":["RGPIN\u20102015\u201004092"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is a remodeling of the central airways in horses with severe asthma but whether a similar process occurs in horses with the mild or moderate asthma (MMA) is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate lesions affecting the central airways of horses with MMA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Twelve horses with MMA and 8 control horses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Case-control retrospective study of horses classified as MMA affected or controls based on history and bronchoalveolar lavage fluid cytology. Endobronchial biopsies were analyzed using histomorphometry and a semiquantitative histologic scoring system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Histomorphometry identified epithelial hyperplasia (47\u2009\u03bcm2\/\u03bcm [34-57\u2009\u03bcm2\/\u03bcm]; P\u00a0=\u00a0.02), a thickened lamina propria (166\u2009\u03bcm [73-336\u2009\u03bcm]; P\u00a0=\u00a0.04), and smooth muscle fibrosis (42% [33%-78%]; P\u00a0=\u00a0.04) in horses with MMA when compared to controls horses (24\u2009\u03bcm2\/\u03bcm [21-80\u2009\u03bcm2\/\u03bcm]; 76\u2009\u03bcm [36-176\u2009\u03bcm]; and 33% [26%-52%], respectively). The semiquantitative score results indicated, in horses with MMA, the presence of epithelial hyperplasia (7 of the 12 horses with MMA and only 1 of the 8 control horses had a score of 1\/1), and submucosal inflammatory leucocytes in the central airway (11 of the 12 horses with MMA and only 4 of the 8 control horses had a score\u2009\u2265\u20091\/2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Relevance<\/jats:title>\n                    <jats:p>Tissue remodeling of the bronchial lamina propria, epithelium, and smooth muscle was present in horses with MMA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16333","type":"journal-article","created":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T03:43:47Z","timestamp":1638935027000},"page":"285-291","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Airway remodeling in horses with mild and moderate asthma"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2763-2916","authenticated-orcid":false,"given":"Amandine","family":"Bessonnat","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Medicine, University of Montreal Department of Clinical Sciences, , Saint-Hyacinthe, Quebec,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"H\u00e9lie","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine , Department of Pathology and Microbiology, University of Montreal, Saint-Hyacinthe, Quebec,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn","family":"Grimes","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine , Department of Pathology and Microbiology, University of Montreal, Saint-Hyacinthe, Quebec,","place":["Canada"]},{"name":"Zoetis Reference Laboratories , San Diego, California,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4655-2102","authenticated-orcid":false,"given":"Jean-Pierre","family":"Lavoie","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, University of Montreal Department of Clinical Sciences, , Saint-Hyacinthe, Quebec,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,1,1]]},"reference":[{"key":"2026020303503076800_jvim16333-bib-0001","doi-asserted-by":"crossref","first-page":"384","DOI":"10.2746\/042516409X366121","article-title":"Influence of subclinical inflammatory airway disease on equine respiratory function evaluated by impulse oscillometry","volume":"41","author":"Richard","year":"2009","journal-title":"Equine Vet J"},{"key":"2026020303503076800_jvim16333-bib-0002","doi-asserted-by":"crossref","first-page":"538","DOI":"10.2460\/ajvr.2001.62.538","article-title":"Clinical signs, evaluation of bronchoalveolar lavage fluid, and assessment of pulmonary function in horses with inflammatory respiratory disease","volume":"62","author":"Couetil","year":"2001","journal-title":"Am J Vet Res"},{"key":"2026020303503076800_jvim16333-bib-0003","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.2042-3306.1982.tb02389.x","article-title":"An assessment of wastage in thoroughbred racing from conception to 4\u2009years of age","volume":"14","author":"Jeffcott","year":"1982","journal-title":"Equine Vet J"},{"key":"2026020303503076800_jvim16333-bib-0004","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1136\/vr.116.3.66","article-title":"Epidemiological study of wastage among racehorses 1982 and 1983","volume":"116","author":"Rossdale","year":"1985","journal-title":"Vet Rec"},{"key":"2026020303503076800_jvim16333-bib-0005","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.2042-3292.2003.tb00216.x","article-title":"Inflammatory airway disease: Defining the syndrome. 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