{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:30:44Z","timestamp":1792798244752,"version":"4.5.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":1435,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T00:00:00Z","timestamp":1643328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Specialization commission (SpezKo) of the Vetsuisse Faculty University of Bern, Switzerland","id":[{"id":"https:\/\/ror.org\/02k7v4d05","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Reticulocyte indices have been suggested as alternatives to transferrin saturation (TSAT) for iron status assessment in humans and dogs but they have not been evaluated thoroughly in cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the value of the reticulocyte indices for the diagnosis of iron deficiency in cats with chronic kidney disease (CKD) and chronic hematuria associated with subcutaneous ureteral bypasses (SUBs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Sixty-four cats: 16 healthy, 14 CKD without SUB, and 34 CKD with SUB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective observational cross-sectional study of cats presented for routine nephrology visits. Primary outcomes included assessment of the diagnostic values of erythrocyte indices (mean corpuscular volume, hemoglobin, and hemoglobin concentration: MCV, MCH, and MCHC) and reticulocyte indices (mean corpuscular volume, MCVr; corpuscular hemoglobin, CHr), using TSAT as reference.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Iron deficiency was diagnosed in 9\/64 cats (14%). A receiver-operating characteristic curve analysis yielded a moderate discriminatory value for CHr in this diagnosis: area under the curve [AUC]\u00a0=\u00a0.75 (95% confidence interval, 0.48-0.89); P\u00a0=\u2009.006; sensitivity 67%, specificity 82% for a cutoff of 15.9\u00a0pg. This compared favorably to MCVr (AUC\u00a0=\u00a0.63; P\u00a0=\u2009.29), MCV (AUC\u00a0=\u00a0.58; P\u00a0=\u2009.45), MCH (AUC\u00a0=\u00a0.64; P\u00a0=\u2009.19), and MCHC (AUC\u00a0=\u00a0.7; P\u00a0=\u2009.03).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Clinical Importance<\/jats:title>\n                    <jats:p>CHr added moderate value to the diagnosis of iron deficiency in cats with CKD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16367","type":"journal-article","created":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T13:08:56Z","timestamp":1643375336000},"page":"619-628","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Diagnostic value of reticulocyte indices for the assessment of the iron status of cats with chronic kidney disease"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6303-5196","authenticated-orcid":false,"given":"Adeline","family":"Betting","sequence":"first","affiliation":[{"name":"Division of Small Animal Internal Medicine , Department of Clinical Veterinary Medicine, Vetsuisse Faculty University of Bern, Bern,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9296-4509","authenticated-orcid":false,"given":"Ariane","family":"Schweighauser","sequence":"additional","affiliation":[{"name":"Division of Small Animal Internal Medicine , Department of Clinical Veterinary Medicine, Vetsuisse Faculty University of Bern, Bern,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6693-5365","authenticated-orcid":false,"given":"Thierry","family":"Francey","sequence":"additional","affiliation":[{"name":"Division of Small Animal 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