{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:14:04Z","timestamp":1790097244780,"version":"4.0.1"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":1435,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acute kidney injury (AKI) is a common, potentially fatal condition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To characterize the etiologies, clinical and clinicopathologic findings, hospitalization period, and outcome of dogs with AKI and to identify markers of negative prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Two hundred forty-nine client-own dogs diagnosed with AKI and hospitalized at a veterinary teaching hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective study. Search of medical records for dogs with AKI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Common clinical signs included lethargy (225\/249, 90%), anorexia (206\/249, 83%), and vomiting (168\/249, 68%). Etiologies included ischemic\/inflammatory (144\/249, 58%), infectious (19\/249, 8%), nephrotoxicosis (14\/249, 6%), or other (13\/249, 5%). Hospital-acquired AKI was diagnosed in 9% (23\/249) of the dogs. Median presentation and peak serum creatinine (sCr) concentrations were 4\u00a0mg\/dL (range, 1.1-37.9) and 4.6\u00a0mg\/dL (range, 1.1-43.1), respectively. Dogs were classified to AKI grades as follows: Grade I, 6 (2%), Grade II, 38 (15%), Grade III, 89 (36%), Grade IV, 77 (31%), and Grade V, 39 (16%). One hundred and sixty-four (66%) dogs survived. There was a positive association between death and AKI grade (P\u00a0=\u2009.009). The case fatality rate was higher among dogs with anuria compared with dogs without anuria (50% vs 28%, respectively; odds ratio [95% confidence interval]: 2.5 [1.39-4.6]; P\u00a0=\u2009.002). Forty-seven (18.8%) dogs underwent hemodialysis, of which 60% survived.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Clinical Importance<\/jats:title>\n                    <jats:p>Two-thirds of dogs with AKI survived. Hospital-acquired AKI was common. The severity of AKI, as reflected by presence of anuria, AKI grade, and other body organs involvement, was associated with the outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16375","type":"journal-article","created":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T07:26:27Z","timestamp":1643700387000},"page":"609-618","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Acute kidney injury in dogs: Etiology, clinical and clinicopathologic findings, prognostic markers, and outcome"],"prefix":"10.1093","volume":"36","author":[{"given":"Dar","family":"Rimer","sequence":"first","affiliation":[{"name":"Veterinary Teaching Hospital, Koret School of Veterinary Medicine, The Hebrew University of Jerusalem , Rehovot,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5549-9484","authenticated-orcid":false,"given":"Hilla","family":"Chen","sequence":"additional","affiliation":[{"name":"Veterinary Teaching Hospital, Koret School of Veterinary Medicine, The Hebrew University of Jerusalem , Rehovot,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mali","family":"Bar-Nathan","sequence":"additional","affiliation":[{"name":"Veterinary Teaching Hospital, Koret School of Veterinary Medicine, The Hebrew University of Jerusalem , Rehovot,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4714-3159","authenticated-orcid":false,"given":"Gilad","family":"Segev","sequence":"additional","affiliation":[{"name":"Veterinary Teaching Hospital, Koret School of Veterinary Medicine, The Hebrew University of Jerusalem , 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