{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T09:21:25Z","timestamp":1778750485687,"version":"3.51.4"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":1435,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T00:00:00Z","timestamp":1644192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Reports of clinicopathologic features of bronchomalacia (BM) differ because of inconsistent definitions and frequent prevalence of comorbid cardiopulmonary disease. Pulmonary hypertension (PH) secondary to BM is poorly described.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Dogs with BM will be older but of any somatotype, and increased expiratory effort, \u22651 comorbid disease, and PH will be more common than in dogs without BM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Client-owned dogs (n\u00a0=\u00a0210) evaluated for respiratory signs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Medical records of dogs with paired inspiratory:\u00a0expiratory-breath-hold computed tomography, tracheobronchoscopy, or both between January 2016 and December 2019 were retrospectively reviewed. Comparisons between dogs with and without BM using Mann-Whitney rank sum or \u03c72 tests (P\u2009&amp;lt;\u2009.05 significant were made). Because of high numbers of variables, criteria with high prevalence (&amp;gt;25%) were identified (n\u00a0=\u00a010) for univariate analysis (P\u2009&amp;lt;\u2009.005 significant). Significant variables were submitted for multivariate analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Bronchomalacia was identified in 41% of dogs of all sizes\/somatotypes; 38% were &amp;gt;10\u00a0kg. All dogs with BM had \u22651 comorbid cardiopulmonary disorder. Dogs with BM were significantly older (P\u2009&amp;lt;\u2009.001), smaller (P\u2009&amp;lt;\u2009.001), and were more likely diagnosed with tracheal or mainstem bronchial collapse (P\u2009&amp;lt;\u00a0.001) or bronchiectasis (P\u2009&amp;lt;\u00a0.001). Multivariate analysis confirmed associations with age, tracheal or mainstem bronchial collapse, and bronchiectasis. In dogs with BM, PH was more prevalent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Although significantly more common in older, smaller dogs, BM occurs in dogs of all sizes and in all instances with comorbidities. Echocardiography should be considered in dogs with BM to identify PH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16381","type":"journal-article","created":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T11:02:22Z","timestamp":1644231742000},"page":"417-428","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Clinicopathologic features, comorbid diseases, and prevalence of pulmonary hypertension in dogs with bronchomalacia"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2987-4700","authenticated-orcid":false,"given":"Jennifer","family":"Gamracy","sequence":"first","affiliation":[{"name":"University of Missouri College of Veterinary Medicine Department of Veterinary Medicine and Surgery, , Columbia, 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