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Mixed modeling was used to evaluate echocardiographic, hs-cTnI, and NT-proBNP differences between groups (GF or GI diet at baseline) over time (1\u2009y after diet change).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ten GF and 10 GI dogs were evaluated. There were statistically significant time: group interactions for hs-cTnI (P\u00a0=\u00a0.02) and normalized left ventricular internal systolic diameter (LVIDsN; P\u00a0=\u00a0.02), with GF dogs showing larger decreases in these variables than GI dogs. Median (range) hs-cTnI (ng\/mL) for GF dogs was 0.141 (0.012-0.224) at baseline and 0.092 (0.044-0.137) at 1\u2009y, and for GI dogs was 0.051 (0.016-0.195) at baseline and 0.060 (0.022-0.280) at 1\u2009y. Median LVIDsN for GF dogs was 1.01 (0.70-1.30) at baseline and 0.87 (0.79-1.24) at 1\u2009y, and for GI dogs was 1.05 (0.84-1.21) at baseline and 1.10 (0.85-1.28) at 1\u2009y.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Decreased hs-cTnI and LVIDsN in GF dogs after diet change supports reversibility of these subclinical myocardial abnormalities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16416","type":"journal-article","created":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T06:05:01Z","timestamp":1649916301000},"page":"1057-1065","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Effect of diet change in healthy dogs with subclinical cardiac biomarker or echocardiographic abnormalities"],"prefix":"10.1093","volume":"36","author":[{"given":"Dana","family":"Haimovitz","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, University of Florida Department of Large Animal Clinical Sciences, , Gainesville, Florida,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Vereb","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, University of Florida Department of Large Animal Clinical Sciences, , Gainesville, Florida,","place":["USA"]},{"name":"College of Veterinary Medicine, Iowa State University , Ames, Iowa,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0569-9557","authenticated-orcid":false,"given":"Lisa","family":"Freeman","sequence":"additional","affiliation":[{"name":"Cummings School of Veterinary Medicine, Tufts University Department of Clinical Sciences, , North Grafton, Massachusetts,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Goldberg","sequence":"additional","affiliation":[{"name":"University of Massachusetts Medical School Department of Population and Quantitative Health Sciences, , Worcester, Massachusetts,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darleen","family":"Lessard","sequence":"additional","affiliation":[{"name":"University of Massachusetts Medical School Department of Population and Quantitative Health Sciences, , Worcester, Massachusetts,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8277-8996","authenticated-orcid":false,"given":"John","family":"Rush","sequence":"additional","affiliation":[{"name":"Cummings School of Veterinary Medicine, Tufts University Department of Clinical Sciences, , North Grafton, 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