{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:39:17Z","timestamp":1770748757757,"version":"3.50.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":1374,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T00:00:00Z","timestamp":1649289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chagas cardiomyopathy, caused by the protozoal parasite Trypanosoma cruzi, is characterized by arrhythmias, myocardial damage, heart failure, and sudden death. We describe 2 dogs with severe, symptomatic Chagas cardiomyopathy characterized by myocardial dysfunction and electrocardiographic abnormalities that were managed with a combination of cardiac medications and antiparasitic treatment with itraconazole and amiodarone. Both dogs died suddenly within 6\u00a0months of diagnosis. These cases highlight the need for early detection of Chagas disease in dogs and continued research to develop effective antiparasitic treatment protocols.<\/jats:p>","DOI":"10.1111\/jvim.16422","type":"journal-article","created":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T07:14:58Z","timestamp":1649315698000},"page":"1100-1105","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Antiparasitic treatment with itraconazole and amiodarone in 2 dogs with severe, symptomatic Chagas cardiomyopathy"],"prefix":"10.1093","volume":"36","author":[{"given":"Elizabeth L.","family":"Malcolm","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine and Biomedical Sciences, Texas A&M University Department of Small Animal Clinical Sciences, , College Station, Texas,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9908-3894","authenticated-orcid":false,"given":"Ashley B.","family":"Saunders","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine and Biomedical Sciences, Texas A&M University Department of Small Animal Clinical Sciences, , College Station, Texas,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3955-5858","authenticated-orcid":false,"given":"Jordan P.","family":"Vitt","sequence":"additional","affiliation":[{"name":"Heart of Veterinary Cardiology PLLC , Seattle, Washington,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno G.","family":"Boutet","sequence":"additional","affiliation":[{"name":"Caring Hearts Veterinary Cardiology , Grande-Digue, New Brunswick,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah A.","family":"Hamer","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine and Biomedical Sciences, Texas A&M University Department of Veterinary Integrative Biosciences, , College Station, Texas,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,5,1]]},"reference":[{"key":"2026020303573523200_jvim16422-bib-0001","doi-asserted-by":"crossref","first-page":"e169","DOI":"10.1161\/CIR.0000000000000599","article-title":"Chagas cardiomyopathy: an update of current clinical knowledge and management: a scientific statement from the American Heart 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