{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T21:29:14Z","timestamp":1770154154783,"version":"3.49.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":1374,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T00:00:00Z","timestamp":1651017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006477","name":"National Taiwan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006477","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["110-2313-B-002-049"],"award-info":[{"award-number":["110-2313-B-002-049"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["107-2311-B-002-011"],"award-info":[{"award-number":["107-2311-B-002-011"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006477","name":"National Taiwan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006477","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["110\u20102313\u2010B\u2010002\u2010049"],"award-info":[{"award-number":["110\u20102313\u2010B\u2010002\u2010049"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["107\u20102311\u2010B\u2010002\u2010011"],"award-info":[{"award-number":["107\u20102311\u2010B\u2010002\u2010011"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Small-breed dogs commonly have concurrent myxomatous mitral valve disease (MMVD) and lower respiratory tract disease (LRTD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis<\/jats:title>\n                    <jats:p>Small-breed dogs with preclinical MMVD and concurrent LRTD have more B-lines on point-of-care lung ultrasound (POC-LUS) compared to dogs without concurrent LRTD and are prone to misdiagnose as cardiogenic pulmonary edema (CPE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>A total of 114 small-breed dogs with preclinical MMVD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective study was conducted, in which POC-LUS was obtained and the number of B-lines was calculated by a single clinician using the Veterinary Bedside Lung Ultrasound Examination protocol. The presence\/absence of LRTD was assessed by clinicians blinded to the POC-LUS results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty and 64 dogs were in ACVIM stage B1 and B2, respectively. The presence of LRTD was prevalent in 74.6% (85\/114) of small-breed dogs with preclinical MMVD. When a previously reported criterion for CPE diagnosis (\u22652 sites with &amp;gt;3 B-lines\/site) was applied, false-positive results were observed in 15.8% (18\/114) of dogs with preclinical MMVD. The summated number of B-lines (3 vs. 1, P\u00a0=\u00a0.003), as well as the false-positive rate (20% vs 3%, P\u00a0=\u00a0.04), were significantly higher in dogs with LRTD compared with dogs without LRTD. Multivariable logistic regression showed the presence of abnormalities other than B-line on POC-LUS (eg, thickened pleura or consolidation) could predict false-positive results (odds ratio\u00a0=\u00a03.75, 95% confidence intervals 1.12-12.54; P\u00a0=\u00a0.03) after adjustment for other clinical and echocardiographic factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Concurrent LRTD and abnormalities other than B-lines should be considered in the interpretation of POC-LUS in MMVD dogs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16428","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T05:27:23Z","timestamp":1651037243000},"page":"1075-1081","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Influence of concurrent lower respiratory tract disease on point-of-care lung ultrasound in small-breed dogs with myxomatous mitral valve disease"],"prefix":"10.1093","volume":"36","author":[{"given":"Man-Cham","family":"Lam","sequence":"first","affiliation":[{"name":"National Taiwan University Veterinary Hospital, National Taiwan University , Taipei,","place":["Taiwan"]},{"name":"Lab of Small Animal Respiratory and Cardiovascular Medicine, TACS-Alliance Research Center , Taipei,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5276-3179","authenticated-orcid":false,"given":"Chung-Hui","family":"Lin","sequence":"additional","affiliation":[{"name":"National Taiwan University Veterinary Hospital, National Taiwan University , Taipei,","place":["Taiwan"]},{"name":"Lab of Small Animal Respiratory and Cardiovascular Medicine, TACS-Alliance Research Center , Taipei,","place":["Taiwan"]},{"name":"Graduate Institute of Veterinary Clinical Sciences, School of 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