{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:28:29Z","timestamp":1782520109352,"version":"3.54.5"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":1374,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T00:00:00Z","timestamp":1651276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Intracranial neoplasia is relatively common in dogs and stereotactic radiotherapy, surgical debulking, or both, are the most successful treatment approaches. A key component of treatment planning involves delineating tumor margin on magnetic resonance imaging (MRI) examinations. How MRI signal intensity alterations relate to histological tumor margins is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Directly compare histological brain sections to MRI sequence images and determine which sequence alteration best correlates with tumor margins.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Five dogs with glioma, 4 dogs with histiocytic sarcoma, and 3 dogs with meningioma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective cohort study. Histological brain sections were registered to in vivo MRI scan images obtained within 7\u2009days of necropsy. Margins of signal intensity alterations (T2-weighted, fluid-attenuating inversion recovery [FLAIR], T1-weighted and contrast enhancement) were compared directly to solid tumor and surgical margins identified on histology. Jacquard similarity metrics (JSM) and cross-sectional areas were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In glioma cases, margins drawn around T2-weighted hyperintensity were most similar to surgical margins (JSM, 0.66\u2009\u00b1\u20090.17) when compared to other sequences. In both meningioma (JSM, 0.57\u2009\u00b1\u20090.21) and histiocytic sarcoma (JSM, 0.75\u2009\u00b1\u20090.11) margins of contrast enhancement were most similar to surgical margins.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Signal intensities correspond to tumor margins for different tumor types and facilitate surgical and radiation therapy planning using MRI images.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16431","type":"journal-article","created":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T03:32:05Z","timestamp":1651289525000},"page":"1039-1048","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Relationship between histological tumor margins and magnetic resonance imaging signal intensities in brain neoplasia of dogs"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4558-0745","authenticated-orcid":false,"given":"Philippa J.","family":"Johnson","sequence":"first","affiliation":[{"name":"Cornell College of Veterinary Medicine, Cornell University Department of Clinical Sciences, , Ithaca, New York,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin C.","family":"Rivard","sequence":"additional","affiliation":[{"name":"Cornell College of Veterinary Medicine, Cornell University Department of Clinical Sciences, , Ithaca, New York,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan H.","family":"Wood","sequence":"additional","affiliation":[{"name":"Cornell College of Veterinary Medicine, Cornell University Department of Clinical Sciences, , Ithaca, New York,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattisen 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