{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T22:44:58Z","timestamp":1774133098839,"version":"3.50.1"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":1268,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T00:00:00Z","timestamp":1659139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Vetoquinol"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In people and dogs, torasemide has higher bioavailability, longer half-life, and longer duration of action than equivalent doses of furosemide but data regarding pharmacological properties of torasemide in cats are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess pharmacokinetic and pharmacodynamic parameters of torasemide in healthy cats, and to investigate the effects of a single administration of torasemide on indicators of diuresis, plasma creatinine concentration, blood pressure, electrolyte concentrations and markers of the renin-angiotensin-aldosterone system (RAAS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Six clinically healthy adult European shorthair cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Randomized 4-period crossover design with 3 groups and 4 treatments. Pharmacokinetic parameters were obtained using a noncompartmental analysis, and the clinically effective dose was assessed using a Hill model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mean absolute bioavailability was estimated at 88.1%. Mean total body clearance was 3.64\u2009mL\/h\/kg and mean terminal half-life was 12.9\u00a0hours. Urine output significantly increased after torasemide administration (P\u2009&amp;lt;\u2009.001). The urine sodium\u00a0:\u00a0potassium ratio (uNa\u00a0:\u00a0uK) paralleled and was statistically correlated to urine output (P\u2009&amp;lt;\u2009.001). Administration of a single torasemide dose led to a significant dose-dependent increase in urine aldosterone\u00a0:\u00a0creatinine ratio (uAldo\u00a0:\u00a0C; P\u2009&amp;lt;\u2009.001) and a transient decrease in plasma potassium concentration (P\u2009&amp;lt;\u2009.001) but did not affect blood pressure or plasma creatinine concentration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>A single torasemide dose leads to a significant increase in diuresis and renin-angiotensin-aldosterone system (RAAS) activation in healthy cats, with high absolute bioavailability, and without clinically relevant adverse effects. Pharmacokinetic parameters indicate that once daily dosing of 0.27\u2009mg\/kg may be appropriate in a clinical setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16500","type":"journal-article","created":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T07:54:15Z","timestamp":1659167655000},"page":"1782-1791","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pharmacokinetic and pharmacodynamic properties of orally administered torasemide in healthy cats"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5117-0638","authenticated-orcid":false,"given":"Marine","family":"Roche-Catholy","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Medicine, Ghent University Small Animal Department, , Merelbeke,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2919-1712","authenticated-orcid":false,"given":"Dominique","family":"Paepe","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Ghent University Small Animal Department, , Merelbeke,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"Devreese","sequence":"additional","affiliation":[{"name":"Pharmacology and Zoological Medicine, Faculty of Veterinary Medicine, Ghent University Department of Pathobiology, , Merelbeke,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6742-3911","authenticated-orcid":false,"given":"Bart J. 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