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Neurolocalization was to the neuromuscular system. Genetic testing for spinal muscular atrophy (LIX1) was negative. Given the progressive nature and suspected poor long-term prognosis, the owners elected euthanasia. Histopathology of skeletal muscle obtained post-mortem disclosed numerous rounded atrophic or hypotrophic fibers with internal nuclei or central basophilic staining. Using oxidative reactions mediated by cytochrome C oxidase and succinic dehydrogenase, scattered myofibers were observed to have central dark staining structures and a \u201cring-like\u201d appearance. Given the cat's age and clinical history, a congenital myopathy was considered most likely, with the central nuclei and \u201cring-like\u201d changes consistent with either centronuclear or myotubular myopathy. Whole genome sequencing identified an underlying missense variant in myotubularin 1 (MTM1), a known candidate gene for X-linked myotubular myopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>New or Unique Information Provided<\/jats:title>\n                    <jats:p>This case is the first report of X-linked myotubular myopathy in a cat with an MTM1 missense mutation. Maine coon cat breeders may consider screening for this variant to prevent production of affected cats and to eradicate the variant from the breeding population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16509","type":"journal-article","created":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T06:43:01Z","timestamp":1660372981000},"page":"1800-1805","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["X-linked myotubular myopathy associated with an\n                    <i>MTM1<\/i>\n                    variant in a Maine coon cat"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1712-9615","authenticated-orcid":false,"given":"Matthew A.","family":"Kopke","sequence":"first","affiliation":[{"name":"School of Veterinary Science, Massey University , Palmerston North,","place":["New Zealand"]},{"name":"Veterinary Nutrition Group , Le Fel,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3332-1359","authenticated-orcid":false,"given":"G. Diane","family":"Shelton","sequence":"additional","affiliation":[{"name":"School of Medicine, University of California San Diego Department of Pathology, , La Jolla, California,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie A.","family":"Lyons","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, University of Missouri Department of Veterinary Medicine and Surgery, , Columbia, Missouri,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith J.","family":"Wall","sequence":"additional","affiliation":[{"name":"School of Veterinary Science, Massey University , Palmerston North,","place":["New Zealand"]},{"name":"Veterinary Nutrition Group , Le Fel,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Pemberton","sequence":"additional","affiliation":[{"name":"School of Veterinary Science, Massey University , Palmerston North,","place":["New 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