{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T11:13:55Z","timestamp":1773054835503,"version":"3.50.1"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":1251,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T00:00:00Z","timestamp":1661212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hyponatremia is common in horses with bacterial pleuropneumonia, but no further characterization of this abnormality has been reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Describe admission plasma sodium concentration ([Na]) in horses with septic pneumopathy and evaluate any association of plasma [Na] with markers of systemic inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Medical records of horses &amp;gt;1\u00a0month of age that between 2008 and 2021 had a transtracheal aspirate (TTA) performed, abnormal TTA cytology, positive TTA culture, pulmonary disease on ultrasonography, radiography or both, and plasma [Na] assessed by direct ion-selective-electrode (dISE). Horses with concurrent diarrhea or azotemia were excluded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Clinical and clinicopathological variables of interest between hypo- and normonatremic horses were compared. Spearman correlation and Fisher exact tests were used to identify significant associations (P\u2009&amp;lt;\u2009.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty of 35 horses had hyponatremia (median, 132\u2009mmol\/L; 25-75th interquartile range [IQR], 129.7-133.1\u2009mmol\/L; reference range, 134.2-138.4\u2009mmol\/L). A higher proportion of horses with systemic inflammatory response syndrome (SIRS) had hyponatremia (P\u00a0=\u00a0.01). Hyponatremic patients had higher mean plasma fibrinogen concentration (461\u2009\u00b1\u2009160.5\u00a0mg\/dL; P\u00a0=\u00a0.01) and higher rectal temperature (38.8\u2009\u00b1\u20090.7\u00b0C; P\u00a0=\u00a0.02) than normonatremic horses. Negative correlations were found between plasma [Na] and fibrinogen (P\u00a0=\u00a0.001; \u03c1\u00a0=\u00a0\u22120.57) concentrations and between plasma [Na] and rectal temperature (P\u00a0=\u00a0.001; \u03c1\u00a0=\u00a0\u22120.51). Presence or absence of pleural effusion did not influence severity of hyponatremia. Mean duration of hospitalization was longer (P\u00a0=\u00a0.04) in hyponatremic horses (9.8\u2009\u00b1\u20096.6\u2009days).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Hyponatremia at admission is associated with the presence of inflammation, SIRS, and with longer duration of hospitalization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16522","type":"journal-article","created":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T03:49:08Z","timestamp":1661226548000},"page":"1820-1826","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Hyponatremia in horses with septic pneumopathy"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3020-420X","authenticated-orcid":false,"given":"Alessandro","family":"Migliorisi","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine and Biomedical Sciences, Colorado State University , Fort Collins, Colorado,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Barger","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, University of Illinois Department of Veterinary Clinical Medicine, , Urbana, Illinois,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Austin","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, University of Illinois Department of Veterinary Clinical Medicine, , Urbana, Illinois,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan 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