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Samples derived from cats with concurrent virus detection were excluded. DCH detection was determined in blood and fresh-frozen liver by quantitative polymerase chain reaction (qPCR) and further investigated in liver sections showing histological parenchymal disorders (HPD) and normal liver (HNL) using in situ hybridization (ISH). Proliferative\/apoptotic activities were determined using immunohistochemistry and ISH panels. Biochemical variables and risk factors for DCH infection were investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Six hundred sixty-one (557 blood and 119 liver samples) cats were included. DCH was detected in 18.50% (103\/557), 13.85% (9\/65), and 3.70% (2\/54) of the blood, HPD, and HNL groups, respectively. Cats with DCH revealed abnormally high activity of aspartate aminotransferase (AST) (P\u00a0=\u00a0.001) and alanine aminotransferase (ALT) (P\u2009&amp;lt;\u2009.001). Among DCH-positive HPD case 2\/9 an 7\/9 were acute and chronic hepatitis, of which 4\/7 had hepatitis. Log viral copy number (LVCN) was positively correlated with ALT (P\u2009&amp;lt;\u2009.001), triglyceride (P\u2009&amp;lt;\u2009.001), and gamma-glutamyl transpeptidase (GGT) (P\u00a0=\u00a0.022). The LVCN also had a positive association with degree of hepatitis (P\u2009&amp;lt;\u2009.05). There was hepatocyte proliferation activity in DHC positive cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Clinical Importance<\/jats:title>\n                    <jats:p>Domestic cat hepadnavirus infection was associated with high serum activity of liver enzymes and chronic lymphoplasmacytic hepatitis (LPH).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16525","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T05:21:27Z","timestamp":1661318487000},"page":"1648-1659","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Domestic cat hepadnavirus associated with hepatopathy in cats: A retrospective 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