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Dogs had an echocardiographic examination, assessment of GFR (iohexol clearance), N-terminal probrain natriuretic peptide (NT-proBNP), and quality of life (QOL) score at baseline and 7 to 10\u2009days after placebo (n\u00a0=\u00a06), SD_pimo 0.2 to 0.3\u00a0mg\/kg q12 (n\u00a0=\u00a012), or HD_pimo 0.5 to 0.6\u00a0mg\/kg q12h (n\u00a0=\u00a012).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No significant differences in GFR or QOL scores were detected between groups (P \u00a0\u2265.07). After HD_pimo, the mean [SD] percent change of NT_proBNP (\u221246.1 [20.2]%), left atrial volume (LAV; \u221227.1 [16.9]%), left ventricular end-diastolic volume (EDV; \u221221.8 [15.0]%), and end-systolic volume (ESV; \u221255.0 [20.7]%) were significantly different (P \u00a0\u2264.004) from placebo (0.5 [19.9]%, 1.3 [15.6]%, \u22120.2 [8.2]%, \u22127.3 [35.6]%, respectively) but not the percent change after SD_pimo (\u221236.6 [16.1]%, \u221222.7 [14.9]%, \u221216.7 [12.5]%, \u221241.6 [14.8]%, respectively; P\u00a0&amp;gt;\u2009.05). After SD_pimo, percent change of NT_proBNP, LAV, EDV, and ESV were significantly different from placebo (P\u00a0&amp;lt;\u2009.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Results suggest that pimobendan (SD_pimo or HD_pimo) might not affect renal function in nonazotemic dogs with stage B2\u2009MMVD. High-dose pimobendan did not demonstrate advantages over SD_pimo within the constraints of our study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16537","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T05:49:03Z","timestamp":1663048143000},"page":"1892-1899","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effect of standard-dose and high-dose pimobendan on select indices of renal and cardiac function in dogs with American College of Veterinary Internal Medicine stage B2 myxomatous mitral valve disease"],"prefix":"10.1093","volume":"36","author":[{"given":"Joanna L.","family":"Kaplan","sequence":"first","affiliation":[{"name":"School of Veterinary Medicine, University of California Department of Medicine & Epidemiology, , Davis, California,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lance C.","family":"Visser","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University of California Department of Medicine & Epidemiology, , Davis, California,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine T.","family":"Gunther-Harrington","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University of California Department of Medicine & Epidemiology, , Davis, California,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric S.","family":"Ontiveros","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University of California Department of Medicine & Epidemiology, , Davis, California,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke A.","family":"Wittenburg","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University of California Department of Surgical & 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