{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T13:54:31Z","timestamp":1772891671961,"version":"3.50.1"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":1190,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T00:00:00Z","timestamp":1665705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"BISSELL Pet Foundation"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Trapped neutrophil syndrome is a rare congenital disease recognized in Border Collies and is characterized by persistent neutropenia with myeloid hyperplasia. The mechanism of neutropenia has not been described. We document the case of a young Border Collie diagnosed with trapped neutrophil syndrome based on clinical features, blood and bone marrow evaluation, and presence of the associated homozygous mutation. Results from flow cytometric and storage studies suggested lower neutrophil survival time. The dog had substantial neutrophilic inflammation in multiple organs, indicating that neutrophils could leave the marrow and enter tissues, making the term \u201ctrapped\u201d neutrophil syndrome a misnomer.<\/jats:p>","DOI":"10.1111\/jvim.16567","type":"journal-article","created":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T07:30:22Z","timestamp":1665732622000},"page":"2170-2176","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Multiorgan neutrophilic inflammation in a Border Collie with \u201ctrapped\u201d neutrophil syndrome"],"prefix":"10.1093","volume":"36","author":[{"given":"Alyssa","family":"Zoto","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, Michigan State University Department of Small Animal Clinical Sciences, , East Lansing, Michigan,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chelsea","family":"Stecklein","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Michigan State University Department of Pathobiology and Diagnostic Investigation, , East Lansing, Michigan,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"Scott","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Michigan State University Department of Pathobiology and Diagnostic Investigation, , East Lansing, Michigan,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Thomas R","family":"Bauer","sequence":"additional","affiliation":[{"name":"Immune Deficiency\u2014Cellular Therapy Program, National Cancer Institute, National Institutes of Health , Bethesda, Maryland,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0047-679X","authenticated-orcid":false,"given":"Cynthia","family":"Lucidi","sequence":"additional","affiliation":[{"name":"Veterinary Diagnostic Laboratory, College of Veterinary Medicine, Michigan State University , Lansing, Michigan,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0236-2307","authenticated-orcid":false,"given":"Harry","family":"Cridge","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Michigan State University Department of Small Animal Clinical Sciences, , East Lansing, Michigan,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,11,1]]},"reference":[{"issue":"6","key":"2026020304040190700_jvim16567-bib-0001","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1080\/00480169.1996.35937","article-title":"Neutropenia with a probable hereditary basis in border collies","volume":"44","author":"Allan","year":"1996","journal-title":"N Z Vet J"},{"issue":"6","key":"2026020304040190700_jvim16567-bib-0002","article-title":"Trapped neutrophil syndrome in a border collie","volume":"56","author":"Hegler","year":"2020","journal-title":"J Am Anim Hosp Assoc"},{"issue":"6","key":"2026020304040190700_jvim16567-bib-0003","first-page":"45","article-title":"Confirmed trapped neutrophil syndrome in a border collie puppy in Israel","volume":"70","author":"Gans","year":"2015","journal-title":"Isr J Vet Med"},{"issue":"6","key":"2026020304040190700_jvim16567-bib-0004","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/jsap.12134","article-title":"Presentation and management of trapped neutrophil syndrome (TNS) in UK border collies","volume":"55","author":"Mason","year":"2014","journal-title":"J Small Anim Pract"},{"issue":"6","key":"2026020304040190700_jvim16567-bib-0005","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1292\/jvms.11-0472","article-title":"Trapped neutrophil syndrome in a border collie dog: clinical, clinico-pathologic, and molecular findings","volume":"74","author":"Mizukami","year":"2012","journal-title":"J Vet Med Sci"},{"issue":"6","key":"2026020304040190700_jvim16567-bib-0006","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/jsap.12938","article-title":"Pyrexia in juvenile dogs: a review of 140 referred cases","volume":"60","author":"Black","year":"2019","journal-title":"J Small Anim Pract"},{"issue":"6","key":"2026020304040190700_jvim16567-bib-0007","first-page":"58","article-title":"Long-term management of trapped neutrophil syndrome in two border collies","volume":"40","author":"Wouda","year":"2010","journal-title":"Aust Vet J"},{"issue":"6","key":"2026020304040190700_jvim16567-bib-0008","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1186\/1471-2164-12-258","article-title":"A canine model of cohen syndrome: trapped neutrophil syndrome","volume":"12","author":"Shearman","year":"2011","journal-title":"BMC Genomics"},{"issue":"6","key":"2026020304040190700_jvim16567-bib-0009","first-page":"1","article-title":"Cohen syndrome: review of the literature","volume":"10","author":"Rodrigues","year":"2018","journal-title":"Cureus"},{"key":"2026020304040190700_jvim16567-bib-0010","doi-asserted-by":"crossref","first-page":"37665","DOI":"10.1074\/jbc.M111.267971","article-title":"Cohen syndrome-associated protein, COH1, is a novel, giant Golgi matrix protein required for Golgi integrity","volume":"286","author":"Seifert","year":"2011","journal-title":"J Biol Chem"},{"issue":"6","key":"2026020304040190700_jvim16567-bib-0011","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/vcp.12220","article-title":"Age-related changes in hematologic and serum biochemical variables in dogs aged 16-60\u2009days","volume":"44","author":"R\u00f8rtveit","year":"2015","journal-title":"Vet Clin Pathol"},{"key":"2026020304040190700_jvim16567-bib-0012","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1186\/s12917-021-02976-w","article-title":"Effect of age, sex, and body size on the blood biochemistry and physiological constants of dogs from 4 wk. to &gt;52 wk. of age","volume":"17","author":"Navarrete","year":"2021","journal-title":"BMC Vet Res"},{"issue":"6","key":"2026020304040190700_jvim16567-bib-0013","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s00109-019-01754-4","article-title":"Serpin B1 defect and increased apoptosis of neutrophils in Cohen syndrome neutropenia","volume":"97","author":"Duplomb","year":"2019","journal-title":"J Mol Med"},{"issue":"6","key":"2026020304040190700_jvim16567-bib-0014","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1365-2052.2005.01413.x","article-title":"Exclusion of CXCR4 as the cause of trapped neutrophil syndrome in border collies using five microsatellites on canine chromosome 19","volume":"37","author":"Shearman","year":"2006","journal-title":"Anim Genet"},{"issue":"6","key":"2026020304040190700_jvim16567-bib-0015","first-page":"778","article-title":"Increased neutrophil adhesive capability in Cohen syndrome, an autosomal recessive disorder associated with granulocytopenia","volume":"83","author":"Olivieri","year":"1998","journal-title":"Hema"},{"issue":"6","key":"2026020304040190700_jvim16567-bib-0016","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1189\/jlb.1003505","article-title":"Mechanisms of glucocorticoid-induced down-regulation of neutrophil L-selectin in cattle: evidence for effects at the gene-expression level and primarily on blood neutrophils","volume":"75","author":"Weber","year":"2004","journal-title":"J Leukoc Biol"},{"key":"2026020304040190700_jvim16567-bib-0017","doi-asserted-by":"crossref","first-page":"4090","DOI":"10.3390\/ijms19124090","article-title":"How glucocorticoids affect the neutrophil life","volume":"19","author":"Ronchetti","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"6","key":"2026020304040190700_jvim16567-bib-0018","doi-asserted-by":"crossref","first-page":"3826","DOI":"10.1210\/en.2006-0142","article-title":"Glucocorticoid modulation of Bcl-2 family members A1 and Bak during delayed spontaneous apoptosis of bovine blood neutrophils","volume":"147","author":"Madsen-Bouterse","year":"2006","journal-title":"Endocrinology"}],"container-title":["Journal of Veterinary Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvim.16567","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jvim.16567","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jvim\/article-pdf\/36\/6\/2170\/66665491\/jvim16567.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jvim\/article-pdf\/36\/6\/2170\/66665491\/jvim16567.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T09:04:23Z","timestamp":1770109463000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jvim\/article\/36\/6\/2170\/8448961"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,1]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,11,1]]}},"URL":"https:\/\/doi.org\/10.1111\/jvim.16567","relation":{},"ISSN":["1939-1676"],"issn-type":[{"value":"1939-1676","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,11]]},"published":{"date-parts":[[2022,11,1]]},"assertion":[{"value":"2022-04-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}