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Dogs were treated with an angiotensin-converting enzyme inhibitor or angiotensin receptor blocker alone or in combination at the attending clinician's discretion and evaluated at 5 time points over 6\u00a0months. Healthy dogs were used to determine the urine aldosterone-to-creatinine ratio cutoff that defined ABT. The relationship of ABT (present at \u226550% of visits) and proteinuria outcome (\u226550% reduction in urine protein-to-creatinine ratio from baseline at \u226550% of subsequent visits) was evaluated. Mixed effects logistic regression was used to evaluate the relationship between clinical variables and outcomes (either successful proteinuria reduction or ABT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty-six percent (20\/56) of dogs had successful proteinuria reduction. Between 34% and 59% of dogs had ABT, depending on the definition used. Aldosterone breakthrough was not associated with proteinuria outcome. Longer duration in the study was associated with greater likelihood of successful proteinuria reduction (P\u00a0=\u00a0.002; odds ratio, 1.6; 95% confidence interval [CI], 1.2-2.2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Aldosterone breakthrough was common in dogs receiving RAS inhibitors for CKDp but was not associated with proteinuria outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16573","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T09:53:21Z","timestamp":1667987601000},"page":"2088-2097","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Prevalence of aldosterone breakthrough in dogs receiving renin-angiotensin system inhibitors for proteinuric chronic kidney disease"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3865-6123","authenticated-orcid":false,"given":"Marisa K.","family":"Ames","sequence":"first","affiliation":[{"name":"Colorado State University College of Veterinary Medicine and Biomedical Sciences Department of Clinical Sciences, , Fort Collins, Colorado,","place":["USA"]},{"name":"School of Veterinary Medicine, University of California, Davis Department of Medicine and Epidemiology, , Davis, California,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4402-7830","authenticated-orcid":false,"given":"Shelly L.","family":"Vaden","sequence":"additional","affiliation":[{"name":"North Carolina State University College of Veterinary Medicine Department of Clinical Sciences, , Raleigh, North 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