{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T09:51:32Z","timestamp":1787392292014,"version":"build-2736575974"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":1070,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T00:00:00Z","timestamp":1674691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Horner syndrome often occurs with cervical myelopathies and might provide insight into the underlying disease and prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To describe the clinical and imaging features of dogs with cervical myelopathy and concurrent Horner syndrome and to determine association of Horner syndrome with diseases or magnetic resonance images (MRI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Ninety-three client-owned dogs with cervical myelopathy and concurrent Horner syndrome and 99 randomly selected client-owned dogs with cervical myelopathy without Horner syndrome (control cases).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective study. Medical records were reviewed to identify Horner and control cases and clinical findings recorded. MRI were reviewed, and lesions characterized and recorded. Descriptive and comparative statistics were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Non-compressive disease occurred more frequently in the Horner group compared with controls (58%; 95% CI: 48-68 vs 9%; 95% CI: 5-16; P\u2009&amp;lt;\u2009.0001). The most common diseases were fibrocartilaginous embolism in the Horner group (44\/93; 47%) and intervertebral disc extrusion (76\/99; 77%) amongst controls. On MRI, parenchymal hyperintensity was seen more commonly in the Horner group (95%; 95% CI: 88-98) compared with controls (51%; 95% CI: 41-60; P\u2009&amp;lt;\u2009.0001). In the Horner group, dogs that did not survive to discharge (N\u00a0=\u00a013) had more extensive MRI lesions relative to the adjacent vertebral length (200%; IQR 110%-575%) compared with survivors (N\u00a0=\u00a080; 110%; IQR 40%-250%; P\u00a0=\u00a0.02). Lateralization of Horner signs and MRI changes matched in 54% of cases. The overall survival rate was high in both Horner (80\/93; 86%) and control (95\/99; 96%) groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Horner syndrome in cervical myelopathy is commonly associated with noncompressive intraparenchymal disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16588","type":"journal-article","created":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T02:38:58Z","timestamp":1674787138000},"page":"598-605","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Horner syndrome as a physiological biomarker of disease in canine cervical myelopathy"],"prefix":"10.1093","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2879-9593","authenticated-orcid":false,"given":"Vishal D.","family":"Murthy","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, University of California Department of Surgical and Radiological Sciences, , Davis, California,","place":["USA"]},{"name":"College of Veterinary Medicine, Washington State University Department of Veterinary Clinical Sciences, , Pullman, Washington,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Phillips","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, University of California Department of Surgical and Radiological Sciences, , Davis, California,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marguerite","family":"Knipe","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, University of California Department of Surgical and Radiological Sciences, , Davis, California,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6862-2653","authenticated-orcid":false,"given":"Michelle","family":"Giuffrida","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, University of California Department of Surgical and Radiological Sciences, , Davis, California,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chai-Fei","family":"Li","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, University of California Department of Surgical and Radiological Sciences, , Davis, California,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,3,1]]},"reference":[{"key":"2026020302540066400_jvim16588-bib-0001","first-page":"202","article-title":"Veterinary Neuroanatomy and Clinical Neurology","author":"de Lahunta","year":"2014","edition":"4th 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