{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T07:58:54Z","timestamp":1778745534216,"version":"3.51.4"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":1129,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T00:00:00Z","timestamp":1669334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001458","name":"American Kennel Club Canine Health Foundation","doi-asserted-by":"publisher","award":["02861-A-(HC)"],"award-info":[{"award-number":["02861-A-(HC)"]}],"id":[{"id":"10.13039\/100001458","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Gastrointestinal Laboratory, Texas A&M University"},{"name":"Michigan State University College of Veterinary Medicine"},{"DOI":"10.13039\/100001458","name":"American Kennel Club Canine Health Foundation","doi-asserted-by":"publisher","award":["02861\u2010A\u2010(HC)"],"award-info":[{"award-number":["02861\u2010A\u2010(HC)"]}],"id":[{"id":"10.13039\/100001458","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The prevalence and clinical importance of cardiac abnormalities in dogs with acute pancreatitis (AP) is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Twelve dogs with AP and 60 archived serum samples from dogs with suspected AP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Two-phase study. Phase I: Analysis of archived serum samples from dogs with clinical signs of AP and high Spec cPL concentrations. High sensitivity troponin I (TnIH) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations were measured in achieved serum samples. Phase II: Prospective observational study. Dogs with AP underwent echocardiography and Holter monitoring. Serum cardiac troponin I (cTnI) and plasma NT-proBNP concentrations were measured. Previously described disease severity indices were calculated for each dog.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Phase I: 41 of 60 dogs suspected of having AP had abnormally high TnIH concentrations and 13 of 60 had abnormally high serum NT-proBNP concentrations. Higher TnIH concentrations were observed in dogs with Spec cPL concentration\u2009&amp;gt;2000\u2009\u03bcg\/L as compared to those with concentrations of 1000-2000\u2009\u03bcg\/L. Phase II: 11 of 12 dogs diagnosed with pancreatitis had abnormal cTnI concentrations (median: 0.384\u2009ng\/mL, range: 0.041-2.966\u2009ng\/mL, RI: \u22640.06\u2009ng\/mL) and 7 of 12 dogs had plasma NT-proBNP concentrations above the reference interval (median: 971\u2009pmol\/L, range: 250-2215\u2009pmol\/L, RI: \u2264900\u2009pmol\/L). Supraventricular and ventricular ectopic beats occurred in 3 dogs. Echocardiographic abnormalities were detected in 5 dogs. Cardiovascular variables were not associated with indices of disease severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Myocardial injury is common in dogs with AP, but clinical consequences appeared to be uncommon in our small cohort. Cardiac biomarkers should be interpreted with caution in dogs with AP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16597","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T08:18:36Z","timestamp":1669364316000},"page":"28-36","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cardiovascular abnormalities in dogs with acute pancreatitis"],"prefix":"10.1093","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0236-2307","authenticated-orcid":false,"given":"Harry","family":"Cridge","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, Michigan State University Department of Small Animal Clinical Sciences, , East Lansing, Michigan,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7726-6307","authenticated-orcid":false,"given":"Daniel K.","family":"Langlois","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Michigan State University Department of Small Animal Clinical Sciences, , East Lansing, Michigan,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3336-2086","authenticated-orcid":false,"given":"J\u00f6rg M.","family":"Steiner","sequence":"additional","affiliation":[{"name":"Gastrointestinal Laboratory, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University , College Station, Texas,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8832-1113","authenticated-orcid":false,"given":"Robert A.","family":"Sanders","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Michigan State University Department of Small Animal Clinical Sciences, , East Lansing, 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