{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:07:44Z","timestamp":1787508464211,"version":"build-2736575974"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":1070,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T00:00:00Z","timestamp":1674172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Open Access funding enabled and organized by Projekt DEAL."}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Surgical abdominal emergencies in calves are associated with a guarded prognosis and have the potential for complex metabolic derangements including acid-base imbalances.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To perform a comprehensive analysis of acid-base status and to assess the prognostic relevance of preoperative clinicopathologic variables in calves undergoing abdominal surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Hospital-based study samples of 535 (dataset 1; DS1) and 83 calves (dataset 2; DS2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective (DS1) and prospective (DS2) case series.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In DS1, acidemia (pH &amp;lt;7.33) was present in 49.9%, whereas alkalemia (pH &amp;gt;7.37) was present in 30.7% of calves. Plasma L-lactate, chloride, and serum inorganic phosphorus concentration accounted for 51.9%, 11.6% and 9.4% of the variation of venous blood pH, respectively. Classification tree analysis indicated that a negative outcome (death or euthanasia during hospitalization) was associated with venous pO2\u2009\u226433.6\u2009mm\u2009Hg, anion gap &amp;gt;18.3 and\u2009&amp;gt;22.9\u00a0mEq\/L, serum albumin concentration\u2009\u226436.5 and\u2009\u226429.4\u00a0g\/L, serum urea concentration\u2009&amp;gt;4.4\u2009mmol\/L, and plasma ionized calcium concentration\u2009\u22641.26\u2009mmol\/L. The area under the receiver operating characteristic curve of this model was 0.85 (95% CI: 0.82-0.89, P\u2009&amp;lt;\u2009.001) and the resulting sensitivity and specificity for the prediction of nonsurvival at the optimal probability cut-point of 0.5 was 89.8% and 65.7%, respectively. In DS2 the model had a similar sensitivity and specificity of 90.5% and 70%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Clinicopathologic imbalances and associated changes of acid-base status are common in calves with surgical abdominal emergencies and have clinical utility for the prediction of a negative postoperative outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16618","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T08:43:52Z","timestamp":1674204232000},"page":"740-756","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Acid-base imbalances and the association of blood-gas variables, electrolytes, and biochemical analytes with outcome in hospitalized calves undergoing abdominal surgery"],"prefix":"10.1093","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9784-8889","authenticated-orcid":false,"given":"Florian M.","family":"Trefz","sequence":"first","affiliation":[{"name":"Clinic for Ruminants with Ambulatory and Herd Health Services at the Centre for Clinical Veterinary Medicine, LMU Munich , Oberschlei\u00dfheim,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinna K.","family":"Lausch","sequence":"additional","affiliation":[{"name":"Clinic for Ruminants with Ambulatory and Herd Health Services at the Centre for Clinical Veterinary Medicine, LMU Munich , Oberschlei\u00dfheim,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Rieger","sequence":"additional","affiliation":[{"name":"Clinic for Ruminants with Ambulatory and Herd Health Services at the Centre for Clinical Veterinary Medicine, LMU Munich , Oberschlei\u00dfheim,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stine","family":"Giertzuch","sequence":"additional","affiliation":[{"name":"Clinic for Ruminants with Ambulatory and Herd Health Services at the Centre for Clinical Veterinary Medicine, LMU Munich , Oberschlei\u00dfheim,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Lorch","sequence":"additional","affiliation":[{"name":"Clinic for Ruminants with Ambulatory and Herd Health Services at the Centre for Clinical Veterinary Medicine, LMU Munich , Oberschlei\u00dfheim,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1929-2106","authenticated-orcid":false,"given":"Peter D.","family":"Constable","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, University of Illinois Urbana-Champaign Department of Veterinary Clinical Medicine, , Urbana, 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