{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:32:36Z","timestamp":1791639156188,"version":"4.3.4"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":948,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T00:00:00Z","timestamp":1680048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Development of a telmisartan-based suppression test may facilitate the diagnosis of primary hyperaldosteronism (PHA) in cats, which remains difficult today.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To develop a telmisartan suppression test (TST) that is safe, and able to suppress aldosterone secretion in healthy cats but not in cats with PHA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Ten healthy cats and 6 cats with PHA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective study using a placebo-controlled crossover design to investigate a TST in healthy cats, and evaluation of TST in cats with PHA. Plasma aldosterone concentration, potassium concentration, and systolic blood pressure (SBP) were measured before (T0), and 1\u2009hour (T1) and 1.5\u2009hours after (T1.5) PO administration of 1\u2009mg\/kg of telmisartan, 2\u2009mg\/kg of telmisartan or placebo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Median age in healthy cats was 3\u2009years old (range, 1-7). In healthy cats, a telmisartan dose of 2\u2009mg\/kg significantly decreased aldosterone concentration at T1 and T1.5 compared with T0. Placebo had no significant effect on aldosterone concentration. In cats diagnosed with PHA, a 2-mg\/kg dose of telmisartan did not induce any significant change in aldosterone concentration at T1 or T1.5 compared with T0. No adverse effects of telmisartan (e.g., hyperkalemia, systemic hypotension) were observed in any cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>The oral TST shows promise as a diagnostic test for the diagnosis of PHA in cats.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16689","type":"journal-article","created":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T12:26:11Z","timestamp":1680092771000},"page":"1341-1347","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of oral telmisartan administration as a suppression test for diagnosis of primary hyperaldosteronism in cats"],"prefix":"10.1093","volume":"37","author":[{"given":"Virginie","family":"Fabr\u00e8s","sequence":"first","affiliation":[{"name":"Ecole Nationale Veterinaire d'Alfort, CHUVA, Service de m\u00e9decine interne , Maisons-Alfort, \u00cele-de-France, F-94700","place":["France"]},{"name":"Centre Hospitalier V\u00e9t\u00e9rinaire Aquivet, Service de m\u00e9decine interne , F-33320 Eysines (Bordeaux),","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6743-7387","authenticated-orcid":false,"given":"Renaud","family":"Dumont","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Veterinaire Fr\u00e9gis, Service de m\u00e9decine interne , 43 avenue Aristide Briand, Arcueil, 94110","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lanie","family":"Garcia","sequence":"additional","affiliation":[{"name":"Micen Vet, Service de m\u00e9decine interne , Cr\u00e9teil,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"Micen Vet, Service de m\u00e9decine 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