{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T10:59:52Z","timestamp":1782125992759,"version":"3.54.5"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":1009,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T00:00:00Z","timestamp":1682467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Hungarian Ministry of Human Resources","award":["12190-4\/2017\/FEKUTSTRAT"],"award-info":[{"award-number":["12190-4\/2017\/FEKUTSTRAT"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>It is unknown whether Dirofilaria repens is capable of causing similar glomerular lesions, as does Dirofilaria immitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine whether D. repens infection could cause albuminuria or proteinuria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Sixty-five clinically healthy laboratory beagle dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this cross-sectional study, dogs were tested for D. repens infection (modified Knott test, PCR test, D. immitis antigen test) and were grouped as \u201cD. repens infected\u201d or \u201ccontrol\u201d dogs. Urinary albumin-to-creatinine ratio (UAC) and urinary protein-to-creatinine ratio (UPC) were measured from samples taken by cystocentesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Forty-three (26 infected, 17 control) dogs were included in the final study group. UAC but not UPC level was significantly higher in the infected group (UAC median 12.5; range, 0-700\u2009mg\/g and UPC median 0.15; range, 0.06-1.06) than in the control group (UAC median 6.3; range, 0-28\u2009mg\/g and UPC median 0.13; range, 0.05-0.64; P\u2009=\u2009.02 and P\u2009=\u2009.65). Overt proteinuria (UPC\u2009&amp;gt;\u20090.5) was present in 6\/26 (23%) of the infected dogs and 1\/17 (6%) of the control dogs. Albuminuria (UAC\u2009&amp;gt;\u200919\u2009mg\/g) was detected in 9\/26 (35%) dogs in the infected group, and 2\/17 dogs (12%) in the control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>D. repens might cause similar glomerular lesions to those caused by D. immitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16712","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T03:47:08Z","timestamp":1682480828000},"page":"992-997","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Albuminuria and proteinuria in dogs infected with\n                    <i>Dirofilaria repens<\/i>\n                    : A cross-sectional study"],"prefix":"10.1093","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3101-6622","authenticated-orcid":false,"given":"Fruzsina A.","family":"Falus","sequence":"first","affiliation":[{"name":"University of Veterinary Medicine Department of Internal Medicine, , Budapest,","place":["Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Korinna \u00c9","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"University of Veterinary Medicine Department of Internal Medicine, , Budapest,","place":["Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsolt","family":"Becker","sequence":"additional","affiliation":[{"name":"University of Veterinary Medicine Department of Internal Medicine, , Budapest,","place":["Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"University of Veterinary Medicine Department of Obstetrics 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