{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T01:40:12Z","timestamp":1788918012992,"version":"build-2803163510"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":948,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T00:00:00Z","timestamp":1684713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Linnaeus Veterinary Limited supported the costs of the open access publication charges."}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Radiotherapy (RT) is an effective treatment for dogs presented with neurologic signs caused by pituitary tumors. However, its impact on the outcome of concurrent pituitary-dependent hypercortisolism (PDH) is controversial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Determine whether dogs with PDH have longer survival after pituitary RT compared with dogs with nonhormonally active pituitary masses and to evaluate whether clinical, imaging, and RT variables affect survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Ninety-four dogs divided into 2 groups: PDH and non-PDH, based on the presence of hypercortisolism. Forty-seven dogs were allocated to the PDH group and 47 to the non-PDH group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective cohort study in which clinical records of dogs undergoing RT for pituitary macroadenomas between 2008 and 2018 at 5 referral centers were retrospectively evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Survival was not statistically different between PDH and non-PDH groups (median survival time [MST], 590\u2009days; 95% confidence interval [CI], 0-830\u2009days and 738\u2009days; 95% CI, 373-1103\u2009days, respectively; P\u2009=\u2009.4). A definitive RT protocol was statistically associated with longer survival compared with a palliative protocol (MST 605 vs 262\u2009days, P\u2009=\u2009.05). The only factor statistically associated with survival from multivariate Cox proportional hazard analysis was total radiation dose (Gy) delivered (P\u2009&amp;lt;\u2009.01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>No statistical difference in survival was identified between the PDH and non-PDH groups, and longer survival was associated with higher Gy delivered.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16724","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T01:50:42Z","timestamp":1684806642000},"page":"1331-1340","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effect of pituitary-dependent hypercortisolism on the survival of dogs treated with radiotherapy for pituitary macroadenomas"],"prefix":"10.1093","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4232-6589","authenticated-orcid":false,"given":"Sofia","family":"Rapastella","sequence":"first","affiliation":[{"name":"Anderson Moores Veterinary Specialists, part of Linnaeus Veterinary Limited, The Granary , Winchester,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6148-4000","authenticated-orcid":false,"given":"Simona","family":"Morabito","sequence":"additional","affiliation":[{"name":"Anicura Ospedale Veterinario I Portoni Rossi , Bologna,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0327-298X","authenticated-orcid":false,"given":"Mellora","family":"Sharman","sequence":"additional","affiliation":[{"name":"VetCT - Teleconsulting Hospital, St John's Innovation Centre Cowley Rd Cambridge , Cambridge,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Benoit","sequence":"additional","affiliation":[{"name":"Oncovet , Villeneuve d'Ascq,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Schiavo","sequence":"additional","affiliation":[{"name":"University of Cambridge Ringgold standard institution - Veterinary Oncology , Cambridge,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Morris","sequence":"additional","affiliation":[{"name":"University of Glasgow School of Veterinary Medicine Ringgold standard institution - Small Animal Hospital , Glasgow,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane Margaret","family":"Dobson","sequence":"additional","affiliation":[{"name":"University of Cambridge, Queen's Veterinary School Hospital Department of Veterinary Medicine, , 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