{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T02:51:24Z","timestamp":1774579884788,"version":"3.50.1"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":948,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T00:00:00Z","timestamp":1684195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Low serum cobalamin concentrations have been associated with ileal malabsorption in dogs with chronic enteropathy. Increased serum methylmalonic acid (MMA) concentrations indicate cobalamin deficiency on a cellular level. Few studies have evaluated serum cobalamin concentrations or methylmalonic acid concentrations in juvenile dogs with parvoviral enteritis or nonparvoviral acute enteropathies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Evaluate serum cobalamin and methylmalonic acid concentrations in juvenile dogs (6\u2009weeks to 10\u2009months old) with parvoviral enteritis or nonparvoviral acute enteropathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Thirty-one juvenile dogs with parvoviral enteritis, 29 dogs with nonparvoviral acute diarrhea (NPVAD), and 40 healthy juvenile control dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Single-center, prospective, observational, cross-sectional study. Serum cobalamin and, when sufficient serum was available, MMA concentrations were measured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Most serum cobalamin concentrations were within the adult reference interval. Serum cobalamin concentrations in healthy dogs (median, 848\u2009ng\/L; range, 293-1912\u2009ng\/L) were significantly higher than in dogs with parvoviral enteritis (P\u2009=\u2009.0002; median, 463\u2009ng\/L; range, &amp;lt;150-10\u2009000\u2009ng\/L) or dogs with NPVAD (P\u2009=\u2009.02; median, 528\u2009ng\/L; range, 160-8998\u2009ng\/L). Serum MMA concentrations were not significantly different between groups (healthy dogs: median, 796\u2009nmol\/L; range, 427-1933\u2009nmol\/L; parvoviral enteritis: median, 858\u2009nmol\/L; range, 554-3424\u2009nmol\/L; NPVAD: median, 764\u2009nmol\/L; range, 392-1222\u2009nmol\/L; P\u2009=\u2009.1).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Juvenile dogs with parvoviral enteritis or NPVAD had lower serum cobalamin concentrations than healthy juvenile dogs. However, based on serum MMA concentrations cellular cobalamin deficiency was not apparent.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16736","type":"journal-article","created":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T04:44:21Z","timestamp":1684212261000},"page":"1368-1375","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Serum cobalamin and methylmalonic acid concentrations in juvenile dogs with parvoviral enteritis or other acute enteropathies"],"prefix":"10.1093","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4456-9536","authenticated-orcid":false,"given":"Michael","family":"Hung","sequence":"first","affiliation":[{"name":"School of Veterinary Medicine & Biomedical Sciences, Texas A&M University Department of Small Animal Clinical Sciences, , College Station, 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