{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T14:35:41Z","timestamp":1773239741597,"version":"3.50.1"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":948,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011004","name":"CASDAR","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011004","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011004","name":"Minist\u00e8re de l'Agriculture et de l'Alimentation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011004","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Nutritional factors are suggested to influence the incidence and severity of glandular gastric disease (GGD) in horses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To retrospectively assess whether dietary fermentable carbohydrates increase the severity of GGD and to prospectively evaluate whether the partial substitution of concentrates by dehydrated alfalfa would decrease GGD severity scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>In total, 82 trotters from 4 training centers exercised \u22655\u2009days\/week.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Multicenter retrospective observational study, and prospective 2-arm randomized trial. Glandular mucosae were observed by gastroscopy and scored (0-4 severity scale) at day 0 (D0). Biochemical composition of the diet fed was compared between ulcerated and nonulcerated groups. After D0, horses either received the same diet (control, n\u2009=\u200941) or pelleted dehydrated alfalfa substituting 50% concentrates (alfalfa, n\u2009=\u200941). Glandular scores were recorded in both groups after 21 (D21) and 42\u2009days (D42). The first end point was a successful outcome, defined as a horse with a glandular score of 2 to 4 on D0, decreasing to a score of 0 to 1 on days 21 or 42.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Horses scored 0 to 1 at D0 ingested more (P\u2009=\u2009.01) soluble sugars from concentrates than those scored 2 to 4 before D0 (77.5\u2009g\/kg BW; 95% confidence interval [CI]: 71.1-84.0, vs 59.1\u2009g\/kg BW; 95% CI: 48.0-70.3), whereas starch intake did not differ between groups (P\u2009=\u2009.24). Among horses scored 2 to 4 at D0, fewer were scored 2 to 4 in the alfalfa group (1 out of 6) compared with the control group (6 out of 6) at D42 (P\u2009=\u2009.02). Clinical success was 47.7 times more likely in horses fed alfalfa compared with horses in the control group (95% CI: 1.6-1422.8).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Clinical Importance<\/jats:title>\n                    <jats:p>Relationships were found between diet composition and integrity of the glandular mucosa. Feeding pelleted dehydrated alfalfa could help to reduce the incidence and severity of GGD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16747","type":"journal-article","created":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T09:05:43Z","timestamp":1685696743000},"page":"1528-1536","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effect of diet composition on glandular gastric disease in horses"],"prefix":"10.1093","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3670-374X","authenticated-orcid":false,"given":"Samy","family":"Julliand","sequence":"first","affiliation":[{"name":"UMR PAM A 02.102 , Dijon,","place":["France"]},{"name":"Lab To Field , Dijon,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjorie","family":"Buttet","sequence":"additional","affiliation":[{"name":"Lab To Field , Dijon,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanguy","family":"Hermange","sequence":"additional","affiliation":[{"name":"Centre Hospitalier V\u00e9t\u00e9rinaire Equin de Livet , Livarot-Pays-d'Auge,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Hillon","sequence":"additional","affiliation":[{"name":"University of Bourgogne-Franche Comt\u00e9 , Dijon,","place":["France"]},{"name":"INSERM U1231, Lipids, Nutrition, Cancer , Dijon,","place":["France"]},{"name":"University Hospital Department of Hepatogastroenterology, , Dijon,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00e9ronique","family":"Julliand","sequence":"additional","affiliation":[{"name":"UMR PAM A 02.102 , Dijon,","place":["France"]},{"name":"University of Bourgogne-Franche Comt\u00e9 , Dijon,","place":["France"]},{"name":"Agrosup Dijon , Dijon,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,7,1]]},"reference":[{"issue":"4","key":"2026020302581692400_jvim16747-bib-0001","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/jvim.15350","article-title":"Management factors and clinical implications of glandular and squamous gastric disease in horses","volume":"33","author":"Sykes","year":"2019","journal-title":"J Vet Intern Med"},{"issue":"4","key":"2026020302581692400_jvim16747-bib-0002","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/evj.12287","article-title":"A comparison of three doses of omeprazole in the treatment of equine gastric ulcer syndrome: a blinded, randomised, dose-response clinical trial","volume":"47","author":"Sykes","year":"2015","journal-title":"Equine Vet J"},{"issue":"4","key":"2026020302581692400_jvim16747-bib-0003","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1111\/evj.12949","article-title":"Risk factors for equine glandular and squamous gastric disease in show jumping warmbloods","volume":"50","author":"Pedersen","year":"2018","journal-title":"Equine Vet J"},{"key":"2026020302581692400_jvim16747-bib-0004","first-page":"880","article-title":"Prevalence of and risk factors for equine glandular and squamous gastric disease in polo horses","volume":"59","author":"Banse","year":"2018","journal-title":"Can Vet J"},{"issue":"4","key":"2026020302581692400_jvim16747-bib-0005","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1186\/s12917-022-03433-y","article-title":"Gut health of horses: effects of high fibre vs high starch diet on histological and morphometrical parameters","volume":"18","author":"Colombino","year":"2022","journal-title":"BMC Vet Res"},{"key":"2026020302581692400_jvim16747-bib-0006","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jevs.2018.02.005","article-title":"Effects of feeding frequency using a commercial automated feeding device on EGUS in exercised QHorses","volume":"64","author":"Luke","year":"2018","journal-title":"J Equine Vet Sci"},{"issue":"4","key":"2026020302581692400_jvim16747-bib-0007","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1248\/bpb.28.1321","article-title":"An overview of acetic acid ulcer models \u2013 the history and state of the art of peptic ulcer research","volume":"28","author":"Okabe","year":"2005","journal-title":"Biol Pharm Bull"},{"key":"2026020302581692400_jvim16747-bib-0008","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.rvsc.2019.04.008","article-title":"Does prebiotic feeding affect equine gastric health? 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