{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T20:22:51Z","timestamp":1770150171099,"version":"3.49.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":948,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T00:00:00Z","timestamp":1686614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A 6-year-old female spayed Great Dane was evaluated for acute onset cluster seizures. Magnetic resonance imaging (MRI) identified a mass in the olfactory bulbs with a large mucoid component caudal to the primary mass. The mass was removed via transfrontal craniotomy and histopathology revealed a tyrosine crystalline-rich, fibrous meningioma with a high mitotic index. Repeat MRI at 6\u2009months showed no detectable tumor regrowth. The dog is clinically normal with no seizures at the time of publication 10\u2009months after surgery. This meningioma subtype is rare in humans. This unique meningioma occurred in a dog of younger age and uncommon breed for intracranial meningioma. Biological progression of this tumor subtype is unknown; however, growth rate might be slow despite the high mitotic index.<\/jats:p>","DOI":"10.1111\/jvim.16789","type":"journal-article","created":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T01:20:54Z","timestamp":1686705654000},"page":"1501-1506","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A novel meningioma with tyrosine-rich crystals in a 6-year-old Great Dane"],"prefix":"10.1093","volume":"37","author":[{"given":"Kara","family":"Majors","sequence":"first","affiliation":[{"name":"Wheat Ridge Animal Hospital , Wheat Ridge, Colorado,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9770-9718","authenticated-orcid":false,"given":"Savannah M.","family":"Rocha","sequence":"additional","affiliation":[{"name":"Colorado State University Department of Environmental and Radiological Health Sciences, , Fort Collins, Colorado,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7443-2912","authenticated-orcid":false,"given":"Rebecca","family":"Windsor","sequence":"additional","affiliation":[{"name":"Wheat Ridge Animal Hospital , Wheat Ridge, Colorado,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald B.","family":"Tjalkens","sequence":"additional","affiliation":[{"name":"Colorado State University Department of Environmental and Radiological Health Sciences, , Fort Collins, Colorado,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Engelien","sequence":"additional","affiliation":[{"name":"Wheat Ridge Animal Hospital , Wheat Ridge, Colorado,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tawfik","family":"Aboellail","sequence":"additional","affiliation":[{"name":"Immunology, and Pathology, Colorado State University Department of Microbiology, , Fort Collins, Colorado,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,7,1]]},"reference":[{"key":"2026020302582684600_jvim16789-bib-0001","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1939-1676.1988.tb02796.x","article-title":"Clinical signs of tumors affecting the rostral cerebrum in 43 dogs","volume":"2","author":"Foster","year":"1988","journal-title":"J Vet Intern Med"},{"key":"2026020302582684600_jvim16789-bib-0002","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.3389\/fonc.2019.01151","article-title":"Canine primary intracranial cancer: a clinicopathologic and comparative review of glioma, meningioma, and choroid plexus tumors","volume":"9","author":"Miller","year":"2019","journal-title":"Front Oncol"},{"key":"2026020302582684600_jvim16789-bib-0003","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1111\/j.1939-1676.2008.00042.x","article-title":"Magnetic resonance imaging and histological classification of intracranial meningiomas in 112 dogs","volume":"22","author":"Sturges","year":"2008","journal-title":"J Vet Intern Med"},{"key":"2026020302582684600_jvim16789-bib-0004","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/vco.12802","article-title":"Standardization of canine meningioma grading: inter-observer agreement and recommendations for reproducible histopathologic criteria","volume":"20","author":"Belluco","year":"2022","journal-title":"Vet Comp Oncol"},{"key":"2026020302582684600_jvim16789-bib-0005","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1111\/jvim.12136","article-title":"Postmortem evaluation of 435 cases of intracranial neoplasia in dogs and relationship of neoplasm with breed, age, and body weight","volume":"27","author":"Song","year":"2013","journal-title":"J Vet Intern Med"},{"key":"2026020302582684600_jvim16789-bib-0006","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1892\/0891-6640(2006)20[669:CIPNC]2.0.CO;2","article-title":"Canine intracranial primary neoplasia: 173 cases (1986-2003)","volume":"20","author":"Snyder","year":"2006","journal-title":"J Vet Intern Med"},{"key":"2026020302582684600_jvim16789-bib-0007","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.tvjl.2011.10.008","article-title":"Canine and feline intracranial meningiomas: an updated review","volume":"192","author":"Motta","year":"2012","journal-title":"Vet J"},{"issue":"4","key":"2026020302582684600_jvim16789-bib-0008","doi-asserted-by":"crossref","first-page":"375","DOI":"10.4314\/ovj.v7i4.14","article-title":"Long-term follow-up of surgical resection alone for primary intracranial rostrotentorial tumors in dogs: 29 cases (2002-2013)","volume":"7","author":"Su\u00f1ol","year":"2017","journal-title":"Open Vet J"},{"key":"2026020302582684600_jvim16789-bib-0009","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/s12917-022-03182-y","article-title":"Clinical presentation, diagnostic findings and outcome of dogs undergoing surgical resection for intracranial meningioma: 101 dogs","volume":"18","author":"Forward","year":"2022","journal-title":"BMC Vet Res"},{"issue":"4","key":"2026020302582684600_jvim16789-bib-0010","doi-asserted-by":"crossref","first-page":"394","DOI":"10.2460\/javma.229.3.394","article-title":"Evaluation of intracranial meningioma resection with a surgical aspirator in dogs: 17 cases (1996-2004)","volume":"229","author":"Greco","year":"2006","journal-title":"J Am Vet Med"},{"issue":"4","key":"2026020302582684600_jvim16789-bib-0011","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.2460\/javma.2002.221.1597","article-title":"Surgery alone or in combination with radiation therapy for treatment of intracranial meningiomas in dogs: 31 cases (1989-2002)","volume":"221","author":"Axlund","year":"2002","journal-title":"J Am Vet Med"},{"issue":"4","key":"2026020302582684600_jvim16789-bib-0012","first-page":"1562","article-title":"Radiosurgery using a stereotactic headframe system for irradiation of brain tumors in dogs","volume":"219","author":"Lester","year":"2011","journal-title":"J Am Vet Med"},{"key":"2026020302582684600_jvim16789-bib-0013","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1892\/0891-6640(1999)013<0408:HRTOBM>2.3.CO;2","article-title":"Hypofractionated radiation therapy of brain masses in dogs: a retrospective analysis of survival of 83 cases (1991-1996)","volume":"13","author":"Brearley","year":"1999","journal-title":"J Vet Intern Med"},{"issue":"4","key":"2026020302582684600_jvim16789-bib-0014","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1292\/jvms.12-0373","article-title":"Surgical resection of twenty-three cases of brain meningioma","volume":"76","author":"Ijiri","year":"2014","journal-title":"J Vet Med Sci"},{"issue":"4","key":"2026020302582684600_jvim16789-bib-0015","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/vco.12054","article-title":"Three-dimensional conformal radiation therapy alone or in combination with surgery for treatment of canine intracranial meningiomas","volume":"13","author":"Keyerleber","year":"2013","journal-title":"Vet Comp Oncol"},{"key":"2026020302582684600_jvim16789-bib-0016","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1080\/019131299281491","article-title":"Case report fibrous meningioma with tyrosine-rich crystals","volume":"23","author":"Couce","year":"1999","journal-title":"Ultrastruct Pathol"},{"issue":"4","key":"2026020302582684600_jvim16789-bib-0017","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1177\/1066896912470165","article-title":"A case of clear cell meningioma with tyrosine-rich crystals","volume":"21","author":"Schollenberg","year":"2013","journal-title":"Int J Surg Pathol"},{"issue":"4","key":"2026020302582684600_jvim16789-bib-0018","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1177\/1066896917727100","article-title":"Meningioma with tyrosine-rich crystalloids: a case report and review of the literature","volume":"26","author":"Reinertsen","year":"2018","journal-title":"Int J Surg Pathol"},{"key":"2026020302582684600_jvim16789-bib-0019","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1354\/vp.39-3-311","article-title":"Immunohistochemical staining patterns of canine meningiomas and correlation with published immunophenotypes","volume":"39","author":"Barnhart","year":"2002","journal-title":"Vet Pathol"},{"issue":"4","key":"2026020302582684600_jvim16789-bib-0020","first-page":"514","article-title":"Long-term chemotherapy with hydroxyurea in a dog with suspected intracranial meningioma","volume":"25","author":"Jung","year":"2008","journal-title":"J Vet Clin"},{"issue":"4","key":"2026020302582684600_jvim16789-bib-0021","doi-asserted-by":"crossref","first-page":"701","DOI":"10.2460\/javma.2000.216.701","article-title":"Influence of tumor cell proliferation and sex-hormone receptors on effectiveness of radiation therapy for dogs with incompletely resected meningiomas","volume":"216","author":"Theon","year":"2000","journal-title":"J Am Vet Med"}],"container-title":["Journal of Veterinary Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jvim\/article-pdf\/37\/4\/1501\/66658966\/jvim16789.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jvim\/article-pdf\/37\/4\/1501\/66658966\/jvim16789.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T07:58:40Z","timestamp":1770105520000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jvim\/article\/37\/4\/1501\/8448034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,1]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,7,1]]}},"URL":"https:\/\/doi.org\/10.1111\/jvim.16789","relation":{},"ISSN":["1939-1676"],"issn-type":[{"value":"1939-1676","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,7]]},"published":{"date-parts":[[2023,7,1]]},"assertion":[{"value":"2023-03-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}