{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:10:35Z","timestamp":1792696235694,"version":"4.5.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":886,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T00:00:00Z","timestamp":1690761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Vitamin E has a positive effect in the management of osteoarthritis in humans, and in a previous study of dogs. It has been suggested to decrease C-reactive protein concentrations and liver enzyme activities in humans and animals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the effect of vitamin E supplementation on lameness, pain, pain medication requirement, clinical pathology variables, and quality of life in large-breed dogs with naturally occurring osteoarthritis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Fifty-seven client-owned dogs with naturally occurring osteoarthritis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Dogs received either vitamin E or placebo for 90\u2009days in a randomized, placebo-controlled, double-blinded, prospective clinical trial. Clinical lameness scores, pain medication requirements, and owner questionnaires were used to assess response to treatment every 30\u2009days. Blood samples were collected at enrollment and at the end of the study period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Vitamin E administration did not improve pain, lameness, or quality of life as assessed by owners and veterinarians. Vitamin E supplementation did not decrease the requirement for rescue pain relief. No changes in clinical pathology variables were observed after 90\u2009days of vitamin E supplementation. Body weight was negatively associated with the lameness scores and requirement for rescue pain relief.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Vitamin E supplementation did not have any observable positive effects in dogs with naturally occurring osteoarthritis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16816","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T09:39:41Z","timestamp":1690796381000},"page":"1839-1847","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A blinded, placebo-controlled study on the clinical effects of vitamin E supplementation in dogs with osteoarthritis"],"prefix":"10.1093","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7475-1283","authenticated-orcid":false,"given":"Casey L.","family":"Gordon","sequence":"first","affiliation":[{"name":"North Coast Veterinary Specialists Department of Surgery, , Sippy Downs, Queensland,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha J.","family":"Reeves","sequence":"additional","affiliation":[{"name":"North Coast Veterinary Specialists Department of Medicine, , Sippy Downs, Queensland,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8527-9308","authenticated-orcid":false,"given":"Richard K.","family":"Burchell","sequence":"additional","affiliation":[{"name":"North Coast Veterinary Specialists Department of Medicine, , Sippy Downs, Queensland,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Thomson","sequence":"additional","affiliation":[{"name":"North Coast Veterinary Specialists Department of Surgery, , Sippy Downs, Queensland,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6449-2812","authenticated-orcid":false,"given":"Arnon","family":"Gal","sequence":"additional","affiliation":[{"name":"University of Illinois Urbana-Champaign Department of Veterinary Clinical Medicine, , Urbana, Illinois,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Lopez-Villalobos","sequence":"additional","affiliation":[{"name":"IVABS, Massey University , Palmerston North,","place":["New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie S. 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