{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T14:12:06Z","timestamp":1789827126139,"version":"4.0.1"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":886,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T00:00:00Z","timestamp":1690761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Serum amyloid A (SAA) is a major acute phase protein in horses which could be a useful tool for assessing clinical response to treatment of bacterial pneumonia in adult horses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To monitor SAA concentration in response to treatment and identify associations among SAA concentration, WBC and neutrophil counts, and fibrinogen in bacterial pneumonia in adult horses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Eighteen adult horses with bacterial pneumonia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective clinical study. Horses hospitalized with bacterial pneumonia were enrolled and SAA concentration and vital signs were assessed daily. SAA concentration was measured by a handheld meter. CBC and plasma fibrinogen were assessed on days 0, 1, and 2, then every 3\u2009days until discharge. Data were not normally distributed and therefore were log transformed. Log-transformed data were analyzed and comparisons were performed on LSMeans by the 2-sided Student's t-test at the 5% level of significance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Geometric mean SAA concentration on day 0 was 537\u2009\u03bcg\/mL (SE 383\u2009\u03bcg\/mL). Geometric mean SAA concentration decreased significantly over time (P\u2009=\u2009.0001), peaking at day 2 (geomean 1038\u2009\u03bcg\/mL, SE 261.7\u2009\u03bcg\/mL) and decreasing until discharge. Plasma concentration of fibrinogen (P\u2009=\u2009.06), neutrophil count (P\u2009=\u2009.48), and WBC count (P\u2009=\u2009.07) did not change significantly over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>SAA concentration decreased significantly over the course of treatment and correlated with clinical improvement of pneumonia whereas fibrinogen, neutrophil, and WBC counts did not.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16818","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T08:27:37Z","timestamp":1690792057000},"page":"1917-1922","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Utility of serum amyloid A in monitoring clinical response to antimicrobial treatment in horses with bacterial pneumonia"],"prefix":"10.1093","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1322-5079","authenticated-orcid":false,"given":"Kate L.","family":"Hepworth-Warren","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, North Carolina State University Department of Clinical Sciences, , Raleigh, North Carolina,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9321-1952","authenticated-orcid":false,"given":"Krista","family":"Estell","sequence":"additional","affiliation":[{"name":"Virginia Tech's Marion duPont Scott Equine Medical Center , Leesburg, Virginia,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bobby","family":"Cowles","sequence":"additional","affiliation":[{"name":"Zoetis , Parsippany, New Jersey,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Amodie","sequence":"additional","affiliation":[{"name":"Zoetis , Parsippany, New Jersey,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7062-2804","authenticated-orcid":false,"given":"Mark","family":"Crisman","sequence":"additional","affiliation":[{"name":"Zoetis , Parsippany, New Jersey,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,9,1]]},"reference":[{"key":"2026020303000533300_jvim16818-bib-0001","first-page":"119","article-title":"Equine Clinical Pathology","author":"Wallace","year":"2014","edition":"1st ed."},{"key":"2026020303000533300_jvim16818-bib-0002","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jevs.2016.09.005","article-title":"Comparison of serum amyloid a in horses with infectious and noninfectious 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