{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:08:53Z","timestamp":1790482133393,"version":"4.1.0"},"reference-count":70,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T00:00:00Z","timestamp":1771027200000},"content-version":"vor","delay-in-days":836,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T00:00:00Z","timestamp":1693872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hyperthyroid cats often have urine specific gravity (USG) values &amp;lt;1.035. It remains unclear how USG changes after treatment, if USG can be used to predict azotemia after treatment, or how iatrogenic hypothyroidism influences USG values.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine the proportion of hyperthyroid cats with USG &amp;lt;1.035 vs \u22651.035; if USG changes after treatment; and whether USG &amp;lt;1.035 correlated with unmasking of azotemia or hypothyroidism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Six hundred fifty-five hyperthyroid cats treated with radioiodine; 190 clinically normal cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective, before-and-after study. Hyperthyroid cats had serum thyroxine, thyroid-stimulating hormone, and creatinine concentrations, and USG measured before and 6\u2009months after successful treatment with radioiodine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of untreated hyperthyroid cats, USG was \u22651.035 in 346 (52.8%) and &amp;lt;1.035 in 309 (47.2%). After treatment, 279\/346 (80.6%) maintained USG \u22651.035, whereas 67\/346 (19.4%) became &amp;lt;1.035; 272\/309 (88%) maintained USG &amp;lt;1.035, whereas 37\/309 (12%) became \u22651.035. Only 22\/346 (6.4%) with USG \u22651.035 developed azotemia after treatment, compared with 136\/309 (44%) with &amp;lt;1.035 (P\u2009&amp;lt;\u2009.001). Of cats remaining nonazotemic, 38% had USG &amp;lt;1.035, compared with 20% of normal cats (P\u2009&amp;lt;\u2009.001). The 137 cats with iatrogenic hypothyroidism had lower USG after treatment than did 508 euthyroid cats (1.024 vs 1.035), but USGs did not change after levothyroxine supplementation. USG &amp;lt;1.035 had high sensitivity (86.1%) but moderate specificity (65.2%) in predicting azotemia after treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Hyperthyroidism appears not to affect USG in cats. However, cats with evidence of sub-optimal concentrating ability before radioiodine treatment (USG\u2009&amp;lt;\u20091.035) are more likely to develop azotemia and unmask previously occult chronic kidney disease. Iatrogenic hypothyroidism itself did not appear to affect USG values.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16849","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T06:54:10Z","timestamp":1693896850000},"page":"2039-2051","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Urine concentrating ability in cats with hyperthyroidism: Influence of radioiodine treatment, masked azotemia, and iatrogenic hypothyroidism"],"prefix":"10.1093","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3016-1855","authenticated-orcid":false,"given":"Mark E.","family":"Peterson","sequence":"first","affiliation":[{"name":"Animal Endocrine Clinic, 21 West 100th Street , New York, New York,","place":["USA"]},{"name":"College of Veterinary Medicine, Cornell University , Ithaca, New 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